Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep205 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Effects of sex steroids on cardiovascular risk profile in female to male transsexuals with cross-sex hormone treatment

Velazquez Gloria Aranda , Porta Mireia Mora , Hanzu Felicia Alexandra , Vera Josep , Ortega Emilio , Halperin Irene

Introduction: In transsexualism, cross-sex hormone treatment (CHT) both improves and impairs several surrogate cardiovascular risk markers in female to male (FtoM). Few randomized trials on CHT with long follow-up and control group are available, and present evidence is inconsistent. We here assess changes in metabolic and cardiovascular risk after 12 months CHT compared with biological sex in FtoM GID.Methods: Prospective observational study, including ...

ea0063p1179 | Thyroid 3 | ECE2019

Sonographic-pathologic correlation of thyroid nodules: TI-RADS vs EU-TIRADS

Ruiz Sabina , Mora Mireia , Aranda Gloria , Hanzu Felicia , Boswell Laura , Squarcia Mattia , Berenguer Joan , Martinez Daniel , Vidal Oscar , Halperin Irene

Background: Several ultrasound (US) scoring systems have been proposed to provide rules for standardizing risk stratification of thyroid nodules and to select which nodules should have a fine needle aspiration (FNA) biopsy performed. TI-RADS classification is one of the most used in the daily practise. Recently, EU-TIRADS scoring system has been published to simplify the evaluation of thyroid nodules and to integrate previous classifications into a single system. We aimed to c...

ea0041ep733 | Neuroendocrinology | ECE2016

Impaired innate immunity in Cushing’s syndrome: increase CD14+CD16++ monocytes

Velazquez Gloria Aranda , Lopez Cristina , Esteban Yaiza , Mora Mireia , Halperin Irene , Casals Gregori , Ensenat Joaquim , Hanzu Felicia Alexandra

Introduction: Chronic hypercortisolism is marked by an increased cardiovascular risk pattern. Atherosclerosis is a chronic inflammation that involves both innate and adaptive immunity. Glucocorticoids (GC) are immune-suppressors and adrenocorticotrophic hormone (ACTH) possesses immune-modulatory activities. GC and ACTH may act in atherothrombotic inflammatory pathways.Aim: To analyze the immune cells pattern in endogenous Cushing syndrome (CS) in order t...

ea0056gp225 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Germline mutations in KIF1B gene in two families with familial non-medullary thyroid cancer (FNMTC)

Anon Aida Orois , Porta Mireia Mora , Rabinovich Irene Halperin , Gara Sudheer Kumar , Kebebew Electron , Ambros Josep Oriola

Introduction: Familial non-medullary thyroid cancer(FNMTC) represents 3–9% of thyroid cancer cases. Although the susceptibility genes for syndromic FNMTC are known, most cases of FNMTC are nonsyndromic and the genetic causes are unknown.Patients and methods: We conducted a multicenter study to identify a candidate susceptibility gene for nonsyndromic FNTMC. We collected blood specimens, clinical and pathological data from 38 kindreds with FNMTC (32 ...

ea0063gp106 | Adrenal and Neuroendocrine - Basic | ECE2019

Gene expression changes in visceral adipose tissue of Cushing syndrome.

Garcia-Eguren Guillermo , Gonzalez Mar , Blanco Enrique , Giro Oriol , Vidal Oscar , Carmona Francesc , Casals Gregori , Mora Mireia , Halperin Irene , diCroce Luciano , Hanzu Felicia A

Introduction: Visceral adipose tissue (VAT) is the key target tissue of glucocorticoids (GC) during active Cushing Syndrome (CS) and a metabolic tissue associated to insulin-resistance and an increased cardiometabolic risk. Till date there are no data regarding gene expression in VAT in CS and only few data about the mRNA in subcutaneous one. The aim of this study was to study the visceral VAT tissue transcriptional changes in ACTH-independent CS.Methods...

ea0049gp24 | Adrenal 3 | ECE2017

Increased exosomes in endogeneous Cushing syndrome

Aranda Gloria , Xifra Gemma , Fernandez-Real Jose Manuel , Garcia-Eguren Guillermo , Casals Gregori , Pane Adriana , Mora Mireia , Halperin Irene , Hanzu Felicia A

Exosomes are nano-sized vesicles secreted by the cells in the exatracellular fluids representing a novel way of intracellular communication. Exosomes secreted from blood cells like monocytes and platetes have been reported to be checkpoints involved in haemostatic and thrombotic response. Glucocorticoids are inducing a profound alteration of blood cells homeostasis with atherothrombotic, bleeding and immune response alterations. Hereby we quantified for the first time circulat...

ea0041gp124 | Neuroendocrinology | ECE2016

Endothelial damage and thrombotic response in patients with cured Cushing syndrome

Aranda Velazquez Gloria , Mora Porta Mireia , Halperin Irene , Fernandez Rebeca , Diaz-Ricart Maribel , Palomo Marta , Vidal Oscar , Ensenat Joaquim , Casals Gregori , Alexandra Hanzu Felicia

Introduction: Clinical observational studies have reported the persistence of a high cardiovascular risk in patients with cured Cushing’s syndrome (CCS) compared with controls of the same age, gender and BMI. It is still at debated whether this is due to the persistence of comorbidities, hormone deficiencies or chronic changes induced by hypercortisolism. The aim of this translational approach was to investigate the interplay in CCS of the cardiovascular disease in vivo a...

ea0037gp.22.06 | Pituitary–Therapy of Cushing's disease | ECE2015

A specific nursing educational programme in patients with Cushing's syndrome

Martinez-Momblan M Antonia , Porta Nuria , Gomez Carmen , Esteve Julia , Santos Alicia , Ubeda Inmaculada , Halperin Irene , Campillo Beatriz , Guillaumet Montserrat , Webb Susan M , Resmini Eugenia

Context: Cushing’s syndrome (CS) is a rare endocrine disease, due to cortisol hypersecretion. CS patients have several comorbidities, often still present after biochemical cure. There are no specific nursing healthcare programs to address this disease and achieve improved health related quality of life (HRQoL). Thus, an educational nursing intervention in these patients, through the development and promotion of specific educational tools, appears to be justified.<p cl...

ea0070aep9 | Adrenal and Cardiovascular Endocrinology | ECE2020

Persistent transcriptional disruption and histone mark modifications on visceral adipose tissue after remission of hypercortisolism

García-Eguren Guillermo , Gonzalez Mar , Vizan Pedro , Giro Oriol , Beyhart Arturo , Mora Mireia , Halperin Irene , Enseñat Joaquim , Vidal Oscar , Carmona Francisco , DiCroce Luciano , Hanzu Felicia

Introduction: Chronic hypercortisolemia during Cushing Syndrome (CS) determines significant changes in the plasticity and function of metabolic tissues like visceral adipose tissue (VAT). Persistence of alterations in VAT function after CS remission is under debate, as data of clinical studies is not consistent due to confounder factors and limited availability of VAT. Animal model of reversible CS presents long-term alterations on VAT after remission. We investigate VAT alter...

ea0032p192 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Effect of cross-sex hormone treatment on lipid profile in transsexual individuals: experience in a specialized unit in Catalonia

Lopez Carmen Quiros , Patrascioiu Ioana , Porta Mireia Mora , Beatriz Gloria , Velazquez Aranda , Hanzu Felicia , Gil Esther Gomez , Sieso Teresa Godas , Rabinovich Irene Halperin

Objectives: To assess baseline differences on lipid profile in individuals with gender identity disorder (male to female, M2F and female to male, F2M) in relation to prior cross-sex hormone treatment (CHT) or not, and changes in the lipid profile after 24 months of treatment and follow-up in our unit.Methods: Transversal study by revision of medical records of 235 patients visited for first time in our service from 2006 to 2010. Clinical and analytical r...