Searchable abstracts of presentations at key conferences in endocrinology

ea0028p347 | Thyroid | SFEBES2012

Rheumatoid Factor interference in TSH assays

Bacon Olivia , Lowery Sarah , Halsall Ian , Chatterjee V , Halsall David

Heterophilic antibody interference in serum TSH immunoassays can result in misdiagnosis of patients with suspected thyroid disease. Rheumatoid factor (RhF) is an immunoglobulin with reactivity to the Fc portion of human IgG. Some RhF species also cross-react with animal immunoglobulins so have the potential to act as heterophile antibodies. As part of the Cambridge Supra-Regional Assay service for thyroid function testing five serum samples with strongly positive RhF and posit...

ea0014p91 | (1) | ECE2007

Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients, who display fat redistribution

Haugaard Steen B , Andersen Ove , Halsall Ian , Iversen Johan , Nicholas Hales Charles , Madsbad Sten

Beta-cell function of HIV-infected patients on highly active antiretroviral therapy (HAART), who display lipodystrophy, may be impaired. An early defect in beta-cell function may be characterized by an increased secretion of 32–33 split proinsulin (SP) and intact proinsulin (IP).To address this issue the secretion pattern of SP and IP of 16 HIV-infected men with lipodystrophy (LIPO) and 15 HIV-infected men without lipodystrophy (NONLIPO) were studie...