Searchable abstracts of presentations at key conferences in endocrinology

ea0020p491 | Obesity and Metabolism | ECE2009

Regulation of novel metabolic regulator fibroblast growth factor-21 by body adiposity and hypercortisolemia: studies in patients with obesity and Cushing’s syndrome

Durovcova Viktoria , Krsek Michal , Hana Vaclav , Marek Josef , Bartlova Marketa , Kavalkova Petra , Haluzik Martin

Fibroblast growth factor-21 (FGF-21) is a novel regulator of metabolic homeostasis that improved diabetes compensation and dyslipidemia in diabetic mice and monkeys. However, little is known about its regulation in humans. Cushing’s syndrome (CS) is characterized by endogenous hypercortisolism and is often associated with numerous metabolic abnormalities. The objective of this study was to test the hypothesis that CS is associated with altered levels of FGF 21 that may in...

ea0020p667 | Reproduction | ECE2009

Selected cytokines are associated with markers of insulin resistance in polycystic ovary syndrome

Stanicka Sona , Vrbikova Jana , Haluzik Martin , Hill Martin , Dvorakova Katerina , Grimmichova Tereza , Vondra Karel

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth fa...

ea0022p706 | Obesity | ECE2010

The influence of weight-loss induced by bariatric surgery on serum concentrations of novel metabolic regulators FGF-21 and FGF-19 in morbidly obese subjects

Haluzikova Denisa , Bartlova Marketa , Mraz Milos , Lacinova Zdena , Krizova Jarmila , Kavalkova Petra , Trachta Pavel , Michalsky David , Kasalicky Mojmir , Haluzik Martin

Objective: Fibroblast growth factor 19 (FGF-19) and FGF-21 are novel metabolic regulators that improve insulin resistence and obesity in rodents. The objective of this study was to explore whether changes in serum concentrations of FGF-19 and FGF-21 contribute to positive metabolic effects of weight loss induced by surgical treatment of obesity – sleeve gastrectomy (SG).Methods: Serum concentrations of FGF-19 and 21, adiponectin, resistin, fatty aci...

ea0081p359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

New insights into obesity treatment provided by smart technologies and telemedicine

Jakubikova Iva , Štolbova Kristyna , Novodvorsky Peter , Dvořakova Iveta , Doležalova Barbora , Kalina Szabolcs , Raška Petr , Kautzner Josef , Haluzik Martin

Introduction: Obesity represents a major public health challenge and is linked with increased risk of multiple medical conditions including atrial fibrillation (AF). We have recently published the study protocol of the ‘The Effect of complex weigHt-reducing interventiOns on rhythm control in oBese subjects wITh Atrial Fibrillation’ (HOBIT-AF) trial. Here we communicate the preliminary results with the focus on the use of smart technologies and telemedicine.<...

ea0022p159 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Changes in serum concentrations and tissue expression of fibroblast growth factor-21 during and after elective major cardiac surgery

Drapalova Jana , Kotulak Tomas , Kopecky Petr , Mraz Milos , Riha Hynek , Blaha Jan , Kramar Petr , Netuka Ivan , Maly Jan , Kremen Jaromir , Kotrlikova Eva , Svacina Stepan , Haluzik Martin

Introduction: Fibroblast growth factor-21 (FGF-21) is a novel regulator of glucose and lipid metabolism and insulin sensitivity. Possible role of FGF-21 in the development of insulin resistance in critically ill patients has not been studied yet.Objective: To study the changes in FGF21 production and adipose tissue and skeletal muscle FGF-21 mRNA gene expression in cardiac surgery patients.Methods: Sixteen patients (16 men, aged 66...

ea0016p51 | Adrenal | ECE2008

Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice

Lamounier-Zepter Valeria , Bornstein Stefan , Kunes Jaroslav , Zicha Jozef , Krsek Michal , Ehrhart-Bornstein Monika , Ziegler Christian , Kiessling Andrea , Funk Richard , Haluzik Martin

The A-ZIP/F-1 transgenic mouse is a model of lipoatrophic diabetes with severe insulin resistance, hyperglycemia and hyperlipidemia. Recently, a regulatory role of adipose tissue on adrenal gland function and blood pressure has been suggested. To further explore the importance of adipose tissue in the regulation of adrenal function and blood pressure, we studied this mouse model of lipodystrophy. A-ZIP/F-1 mice exhibit significantly elevated systolic and diastolic blood pressu...