ea0042oc2 | (1) | Androgens2016
Laurent Michael R
, Antonio Leen
, Blokland Marco H
, Sterk Saskia S
, Jardi Ferran
, Dubois V
, Kaufman Jean-Mark
, Fiers Tom
, Huhtaniemi Ilpo T
, Hammond Geoffrey T.
, Vanderschueren Dirk
, Claessens Frank
Sex hormone-binding globulin (SHBG) is a high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG regulates the free sex steroid fraction and restricts androgen bioactivity. SHBG has also been independently associated with diabetes, osteoporosis etc., but whether this represents causality or residual confounding remains unconfirmed. We studied mice overexpressing human SHBG. Using multiligand liquid chromatography ta...