Searchable abstracts of presentations at key conferences in endocrinology

ea0015p120 | Diabetes, metabolism and cardiovascular | SFEBES2008

Care of diabetic inpatients: the role of diabetic nurse specialists

Pollara Gabriele , Han Thang , Tindall Hilary

Objectives: Patients with diabetes have longer and more complicated hospital stays than non-diabetic patients. The 2001 UK National Service Framework (NSF) recommends that the management of these patients should be supplemented by diabetes nurse specialists (DNS). This study aimed to audit the implementation of this recommendation, how it can be targeted and the impact it has on patient care.Study design and setting: One month long cross-sectional study ...

ea0038p205 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evaluation of adipocytokines and traditional cardiometabolic risk factors in young male cancer survivors: an age-matched control study

Greenfield Diana , Blewitt Alice , Coleman Robert , Walsh Jennifer , Snowden John , Ross Richard , Han Thang

Background: Life expectancy of cancer survivors has doubled in the past four decades; however, death due to cardiovascular disease is more prevalent in survivors than the general population.Objective, design and methods: We evaluated novel and traditional cardiometabolic risk factors in young male cancer survivors in a cross-sectional study of male cancer survivors aged 25–45 years compared with age-matched non-cancer controls. Demographic and anthr...

ea0021p284 | Pituitary | SFEBES2009

Validity of the new pituitary apoplexy guideline group scoring system (PAGGS) in the management of pituitary apoplexy: a large retrospective review of 46 patients with classical pituitary apoplexy

Rajasekaran Senthil , Reddy Narendra , Han Thang , Vanderpump Mark , Baldeweg Stephanie , Wass John

Background: There is lack of consensus in the management of pituitary apoplexy. Following the 11th Clinicopathological Pituitary Conference at the RCP (2009), a multidisciplinary group produced evidence-based guidelines for management of apoplexy. A patient with apoplexy and significant neuro-ophthalmic signs or reduced level of consciousness will usually undergo surgical decompression. It is unclear what defines a significant neuro-ophthalmic deficit. There is no objective to...

ea0034p160 | Growth and development | SFEBES2014

Relationships between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

Han Thang , Stimson Roland , Rees Aled , Krone Nils , Willis Debbie , Conway Gerard , Arlt Wiebke , Walker Brian , Ross Richard

Background: Treatment of congenital adrenal hyperplasia (CAH) in childhood focuses on growth and development; however the relationship of childhood treatment with adult health outcomes is not established. We explored this by examining relationships between final height (FH) and cardiometabolic risk in CAH adults.Methods: Cross-sectional analysis of 65 men (80% salt wasting (SW) and 20% non-SW) and 134 women (74% SW and 26% non-SW), aged 18–69 years....

ea0035oc5.2 | Adrenal & Thyroid | ECE2014

Relationship between final height and cardiometabolic risk and quality of life in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

Han Thang S , Conway Gerard S , Krone Nils , Aled Rees D , Stimson Roland H , Arlt Wiebke , Walker Brian R , Ross Richard J

Background: Treatment of CAH in childhood focuses on growth and development; however the impact of final height (FH) on adult health is not known. We examined the relationship between FH, adiposity, cardiometabolic risk and quality of life (QoL) in a cohort of adult patients.Methods: Cross-sectional analysis of 199 adults with CAH. FH, waist circumference (WC) and QoL were expressed as z-scores adjusted for mid-parental target height (FHTH<...

ea0031p331 | Steroids | SFEBES2013

Quality of life relates to glucocorticoid treatment regimen, adiposity and insulin resistance in adults with congenital adrenal hyperplasia: UK Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

Han Thang S , Krone Nils , Willis Debbie S , Conway Gerard S , Aled Rees D , Stimson Roland H , Walker Brian R , Arlt Wiebke , Ross Richard J

Background: Quality of life (QoL) has been variously reported as normal or impaired in congenital adrenal hyperplasia (CAH) adults. We found impaired QoL in UK CAH adults and now report the relationship between QoL, glucocorticoid treatment and health outcomes in these patients.Methods: Cross-sectional analysis of 151 CAH adults with 21-hydroxylase deficiency aged 18–69 years in whom QoL (SF-36), glucocorticoid regimen, anthropometric, and metabolic...

ea0021p160 | Diabetes and metabolism | SFEBES2009

Total pancreatectomy and pancreatic islet autotransplantation in patient with intractable pain caused by chronic pancreatitis

Han Thang , Abdurahman Shna , Jones Gareth , Kumar Anila , Lowdell Mark , Pratt Julian , Powis Stephen , Rolles Keith , Rosenthal Miranda , Press Martin , Kurzawinski Tomasz

Total pancreatectomy for chronic pancreatic pain is often deferred because it leaves the patient with unstable insulin-dependent diabetes. NICE (2008) has recently approved pancreatectomy with simultaneous islet autotransplantation and we here describe our first case. A 49-year-old female with a 6-year history of intractable, opioid requiring abdominal pain had become depressed to the point of suicide attempts. Imaging showed pancreatic atrophy and duct irregularity (subsequen...

ea0028p306 | Steroids | SFEBES2012

Genotype-phenotype correlation in 153 adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency - analysis of the United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE) cohort

Krone Nils , Rose Ian , Willis Debbie , Wild Sarah , Hodson James , Doherty Emma , Hahner Stefanie , Parajes Silvia , Stimson Roland , Han Thang , Carroll Paul , Conway Gerard , Walker Brian , Macdonald Fiona , Ross Richard , Arlt Wiebke , CaHASE The UK CAH Adult Study Executive

In congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency a genotype-phenotype correlation exists for paediatric cohorts, helping to predict the severity of disease expression. Data on the correlation in adults is lacking. Here we report the genetic analysis of the UK CaHASE cohort, comprising CAH adults seen at 17 endocrine tertiary care centres. CYP21A2 mutation analysis was performed in 153 patients (median age 35 (range 18–69) yrs; 103 f, 50 m) by multi...

ea0037gp.08.01 | Reproduction: Male and endocrine disruptors | ECE2015

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Ahern Tomas B , Huhtaniemi Ilpo T , Carter Emma L , Finn Joseph D , Pye Stephen R , O'Neill Terence W , Bartfai Gyorgy , Casanueva Felipe F , Forti Gianni , Giwercman Aleksander , Han Thang S , Kula Krzysztof , Lean Michael EJ , Pendleton Neil , Punab Margus , Vanderschueren Dirk , Wu Frederick C W

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 40–79 in eight ...

ea0025oc3.8 | Pituitary and thyroid | SFEBES2011

Assessment of the UK iodine status: a National Survey

Vanderpump Mark , Lazarus John , Smyth Peter , Burns Robert , Eggo Margaret , Han Thang , Williams Graham , Torlinska Barbara , Mullan Karen , Pearce Simon , Razvi Salman , Lean Mike , Aspray Emile Combet , Bannon Denise , Abraham Prakash , Vadia Bijay , Leese Graham , Laurberg Peter , Boelaert Kristien , Franklyn Jayne

Inadequate dietary iodine intake is the most common cause of preventable mental impairment worldwide and is defined by the WHO as a population median urinary iodine (UI) excretion <100 μg/l. No contemporary data are available for the UK according to the ICCIDD. The UK has no programme of food/salt iodination.We have performed a systematic assessment of the current UK iodine status in 14–15 years old schoolgirls. Seven hundred and eighty-fiv...