Endocrine Abstracts

Introduction: Langerhans cell histiocytosis (LCH) is a rare disease with incidence of 1–2 adults per milion/year. Pituitary function is affected in 30% of cases presenting almost always with diabetes insipidus. Other deficiencies such as GH, FSH+LH, TSH and ACTH follow. Erdheim–Chester disease is a rare Non-LCH described in several hundreds of cases in the world so far, with the pituitary function involvement in similar frequency as in LCH.Case...

Introduction: Dexamethasone induced negative feedback on CRH, ACTH and cortisol secretion is one of the key principles in the diagnostic workup of hypercortisolism. Cortisol secretion has been studied extensively, but changes of other steroids remained apart. Our aim was to establish steroid profile changes in 1 mg dexamethasone test.Methods: The Steroid profile consisting of 103 steroids and their metabolites from the serum of 9 male and 8 healthy femal...

Androgen secreting adrenal tumor is a rare cause of androgen excess in women. There are only few case-reports of androgen producing adenoma in a patient with congenital adrenal hyperplasia.Our patient, 61 year old woman was referred to our department for progressive hirsutism and androgenic alopecia. She did not mention neither excessive facial hair growth nor balding until age of 59 when rapidly progressive balding and overt hirsutism started. She has h...

Introduction: A key feature of a benign adrenal tumor is its hormonal production. It is reflected by serum steroid levels. A tumoral tissue steroid content is not commonly measured.Methods: A steroid metabolome comprising of 65 steroids was measured in four samples from each of two patients using GC-MS in serum before and after 1mg dexamethasone test, in the tumoral tissue and in the adrenal tissue of two female patients with adrenal adenomas. The first ...

Introduction: Acromegaly with GH excess affects up to 20% of the patients with McCune–Albright syndrome (MAS). Surgical treatment for acromegaly in MAS is often difficult because of skull-base dysplasia. Somatostatin analogs are frequently only partially effective and GH receptor antagonist – pegvisomant is more potent in normalizing IGFI levels. Radiotherapy is controversial. Pregnancy in MAS patients is described in literature but no case of successful delivery in ...

Introduction: Gas chromatography tandem mass spectrometry (GC-MS/MS) quantitatively detects a large number of steroids at one time in a single serum sample. Most studies of subclinical hypercortisolism in adrenal incidentalomas have focused on detection of a few steroids like cortisol, DHEA/S, androstenedione, testosterone. We used GC-MS/MS to quantify 91 steroids in patients with adrenal incidentalomas to search for the most reliable marker of subclinical hypercortisolism.</p...

Introduction: In the past 10 years, endoscopic resection of pituitary adenomas has become an alternative to microsurgical resection with the additional advantage of increasing the patient’s postoperative comfort. This analysis explored whether endoscopic resection can reduce the risk of postoperative neurohypophyseal dysfunction.Material and methods: We rated and compared the need to administer desmopressin during the first four postoperative days a...

Introduction: Salivary cortisol measurement, representing free cortisol, seems to be a promissing alternative method to serum cortisol. Besides its use in the diagnostics of hypercortisolism, it could be of help in evaluation of adrenocortical reserve. It might be useful especially in patients on estrogen replacement, which modulates transcortin and hence total cortisol levels.Aims: Compare the reliability of salivary vs. serum cortisol assessment during...

Certain degree of hypopituitarism has been revealed in a significant number of patients who suffered traumatic brain injuries or subarachnoid hemorrhage. Microhemorrhages, necrosis, tissue infarcts and vasoconstriction are reported as mechanism of hypothalamo-pituitary dysfunction. Assessment of hypothalamo-pituitary endocrine functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo-pituitary unit can be expected (he...

Fibroblast growth factor-21 (FGF-21) is a novel regulator of metabolic homeostasis that improved diabetes compensation and dyslipidemia in diabetic mice and monkeys. However, little is known about its regulation in humans. Cushing’s syndrome (CS) is characterized by endogenous hypercortisolism and is often associated with numerous metabolic abnormalities. The objective of this study was to test the hypothesis that CS is associated with altered levels of FGF 21 that may in...