Searchable abstracts of presentations at key conferences in endocrinology

ea0004p34 | Cytokines and growth factors | SFE2002

IGFBP-3 mRNA expression is reduced in normal colonic mucosa of colorectal patients with colorectal cancer compared to mucosa from non cancer patients

Ogunkolade B , Kelly|P## , S##Khalaf P , Fairclough P , Li R , Ahmed S , Hands R , Bustin S , Jenkins P

Background:Circulating levels of IGFBP-3 are inversely associated with the risk of developing colorectal cancers (CRC). In addition to modulating IGF bioavailability, IGFBP-3 also exerts independent pro-apoptotic effects. Furthermore, the mode of action of several apoptotic and antiproliferative agents, including vitamin D, has been shown to involve induction of IGFBP-3.Aims:To quantitate and compare IGFBP-3 ...