ea0094oc4.6 | Reproductive Endocrinology | SFEBES2023
Xu Ruijuan
, Sureshkumar Sumetha
, Agwuegbo Uche
, Tran Hanh
, Hopkins Thomas
, Bousfield George
, Jonas Kim
Follicle stimulating hormone (FSH) is a heterodimeric glycoprotein hormone, crucial for regulating female reproduction. Its actions are mediated through FSHR, a Class A G protein-coupled receptor (GPCR), which primarily couples to Gs/cAMP/PKA pathway to modulate ovarian follicle growth, granulosa cell proliferation, and estrogen production. In addition to dogmatic functions of FSH in reproduction, there is increasing evidence that FSH can act on extragonadal tissues. Specifica...