Searchable abstracts of presentations at key conferences in endocrinology

ea0014p170 | (1) | ECE2007

Leptin modulates the growth of murine Colon 38 cancer and interferes with the cytotoxic effect of fluorouracil in vitro

Melen-Mucha Gabriela , Lawnicka Hanna

Epidemiological studies underline that obesity represents a significant risk factor for development of several cancer among them colon cancer. Moreover, multiple recent data indicate that some of adipose tissue-derived hormones may influence the growth of malignant cells. Leptin, the product of the ob gene, is one of them. However, research is still contradictory regarding the role of leptin in colon cancer.The aim of our study was to examine the ...

ea0014p144 | (1) | ECE2007

Angiotensin 4–8 and angiotensin 5–8 inhibit cell proliferation in GH3 rat pituitary lactosomatotroph tumor cell culture

Ptasinska-Wnuk Dorota , Kunert-Radek Jolanta , Lawnicka Hanna , Pawlikowski Marek

Introduction: In many tissues angiotensin peptides acts as the auto/paracrine growth factors. Their effects are dependent on activation of various intracellular signaling pathways, including mitogen-activated protein kinases (MAPK).Angiotensin II (ang II) is the best known angiotensin peptide. The ang II derivatives, angiotensin III (ang III) and angiotensin IV (ang IV) posses biological activity as well. Both ang II and ang IV are known to promote the p...

ea0035p565 | Endocrine tumours and neoplasia | ECE2014

Effect of thiazolidinediones: PPARγ agonists on hormones secretion by cells of human adrenocortical cancer in vitro

Fuss-Chmielewska Julita , Lawnicka Hanna , Swietoslawski Jacek , Beda-Maluga Karolina , Winczyk Katarzyna

Introduction: Adrenocortical carcinoma (ACC) is characterized by the high malignancy of the lesion, poor prognosis and high mortality rate. The surgical treatment and available chemotherapy have generally low efficacy so the search for new therapeutic options is still necessary. Some research indicated that thiazolidinediones (TZDs)–synthetic ligands of peroxisome proliferator-activated receptor γ (PPARγ) have oncostatic action on neoplasm, including endocrine t...

ea0014p160 | (1) | ECE2007

Inhibitory effect of rosiglitazone – PPARgamma receptor ligand on growth of human adrenocortical tumor cells in vitro

Winczyk Katarzyna , Lawnicka Hanna , Fuss-Chmielewska Julita , Kolomecki Krzysztof , Kuroszczyk Jacek , Pawlikowski Marek

Introduction: The peroxisome proliferator-activated receptors gamma (PPARγ) are nuclear receptors which are detected in normal and pathological tissues. Our earlier study showed the overexpression of PPARγ in human adrenal tumors and pituitary adenomas in comparison to normal glands. The in vitro experiments indicated that ligands of PPARγ inhibit growth of many tumors including pituitary adenomas, thyroid cancers and adrenal carcinomas. However, the data...