Searchable abstracts of presentations at key conferences in endocrinology

ea0034p259 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Decrums disease: an unusual case of bilateral adrenal lipomas

Hannon Anne Marie , Owens Lisa , O'Halloran Domhnall

Decrum’s disease or adiposis dolorasa is a rare progressive syndrome of unknown aetiology. It is characterised by painful fatty deposits, general obesity, weakness and unexplained emotional disturbance.1We describe a case of a 55-year-old man who presented with pneumonia. On examination he was noted to be overweight and have multiple skin nodules. His chest X-ray was abnormal; he underwent further workup with a CT thorax/abdomen/pelvis. T...

ea0034p405 | Thyroid | SFEBES2014

Scalp metastasis in follicular thyroid cancer: an atypical consequence

Hannon Anne Marie , O'Brien Frank , Fitzgerald Deirdre , Tuthill Antoinette

Follicular thyroid cancer is the second most common cause of thyroid carcinoma. Metastasis occurs in 10–15% of cases. Typical sites of metastasis include bone and lungs, scalp metastasis are rare, with <50 cases reported. We describe two such cases.A retrospective chart review was performed on these patients, examining presentation, treatment and subsequent outcomes.Patient 1. An abnormal lesion was noted on a routine ches...

ea0074oc9 | Oral Communications | SFENCC2021

Cardiac arrhythmia and ischaemic stroke in a young man with Resistance to Thyroid Hormone beta

Hannon Anne Marie , Kinsella Justin , Crowley Rachel , Moran Carla

Case history: A 42 year old male teacher presented to the emergency department with an acute right MCA infarct, on a background of paroxysmal atrial fibrillation/flutter and recurrent supraventricular tachycardia. He had chronic palpitations, with previous failed cardiac ablation. He had no other medical history, specifically, no history of ear infections or learning difficulties. There was no known family history of thyroid dysfunction. Previous TSH levels (no FT4 measurement...

ea0049ep1041 | Pituitary - Clinical | ECE2017

Idiopathic isolated acquired ACTH deficiency– a case series from the Irish National Pituitary Network

Hannon Anne marie , Smith Diarmuid , Sherlock Mark , Hunter Steven , Thompson Chris

Idiopathic Isolated ATCH deficiency (IIAD) is a rare cause of secondary adrenal insufficiency characterised by ACTH deficiency with otherwise intact pituitary function. Our objective was to describe the presentation, the autoimmune associations and diagnostic findings observed in IIAD. We present a case series of 19 cases of idiopathic Isolated ACTH deficiency which were identified from the National Pituitary Register in Ireland. A chart and biochemical review was performed to...

ea0059p141 | Neuroendocrinology and pituitary | SFEBES2018

Active management of severe hyponatraemia by endocrinologists is associated with lower mortality

Garrahy Aoife , Hannon Anne Marie , Cuesta Martin , Murphy Bryan , Tormey William , Sherlock Mark , Thompson Chris

Severe hyponatraemia (SHN, <120 mmol/l) is reported to be associated with mortality as high as 50%; although there are several international guidelines for management of SHN, there are few data on the impact of treatment. We have longitudinally audited our treatment outcomes of SHN. We present the results of three audit periods, of six months each, from 2005, 2010 and 2015. The three periods represented; 2005, prior to hospital policy for SHN, 2010, audit of impact of poli...

ea0034p302 | Pituitary | SFEBES2014

Primary polydipsia in a family with a known mutation in the AVP gene

Casey Ruth , Hannon Anne Marie , Joyce Caroline , O'Connell Susan , O'Halloran Domhnall

Diabetes insipidus is characterised clinically by the inappropriate production of large volumes of dilute urine, even in the presence of clinical dehydration or depravation of water. DI occurs either due to deficiency or insufficiency of arginine vasopressin (AVP) hormone production. The gold standard test remains the water deprivation test. Hereditary DI accounts for <10% of all cases.We present a family with a known heterozygous missense mutation, ...

ea0065p13 | Adrenal and Cardiovascular | SFEBES2019

Seasonal vaccination and associated steroid management practice in adrenal insufficiency

O'Murchadha Liam , Dib Liana , Hannon Anne Marie , Dineen Rosemary , Garrahy Aoife , Thompson CJ , Fitzpatrick Fidelma , Sherlock Mark

Background: Adrenal insufficiency remains a potentially life-threatening condition, necessitating adequate glucocorticoid replacement and appropriate stress-related adjustment to avoid crisis. Flu-like illness is a key precipitant of adrenal crisis. While some authorities recommend annual influenza vaccination for such patients, uptake rates in this population are unknown. Additionally, while seasonal vaccines may lead to minor symptoms in the general population, there are no ...

ea0041ep877 | Pituitary - Clinical | ECE2016

“The incidence of central adrenal insufficiency in euvolaemic hyponatraemia. Results of a large prospective study”

Cuesta Martin , Slattery David , Garrahy Aoife , Hannon Anne Marie , Tatro Elizabeth , Gupta Saket , Sherlock Mark , Tormey William , Thompson Christopher J

Context: The syndrome of inappropriate antidiuresis(SIAD) is the commonest cause of hyponatraemia. Data on the aetiology of SIAD is mainly derived from retrospective studies, often with poor ascertainment of minimum criteria for correct diagnosis. Although central adrenal insufficiency(CAI) is known to cause euvolaemic hyponatraemia, the incidence of undiagnosed CAI in SIAD is unknown.Objective: To establish the incidence of CAI in SIAD.<p class="abs...

ea0059p135 | Neuroendocrinology and pituitary | SFEBES2018

Bolus 3% saline restores cognitive function more rapidly than traditional slow intravenous infusion of 3% saline in the emergency treatment of SIAD, with symptoms of cerebral irritation

Garrahy Aoife , Dineen Rosemary , Hannon Anne Marie , Zia-ul-Hussnain HM , Cuesta Martin , Sherlock Mark , Thompson Chris

Acute hyponatraemia is a medical emergency with high mortality. Recent expert guidelines advocate treatment with intravenous boluses of 3% saline with the aim to reduce cerebral oedema more rapidly than traditional slow intravenous infusion, but there is a poor evidence base for this policy change. We retrospectively audited treatment of symptomatic hyponatraemia due to SIAD (n=57, age 22–76 year), comparing low dose (20 ml/h) and bolus infusion of 3% saline. Bol...

ea0037ep1226 | Clinical Cases–Pituitary/Adrenal | ECE2015

A case of IgG4 related hypophysitis in a Caucasian female

Hannon Anne Marie , Gupta Saket , Slattery Dave , McGurran Karen , Kinsley Brendan , Javadpour Moshen , Brett Francesca , Agha Amar

IgG4 related hypophysitis is a recently described entity belonging to the IgG4 related diseases. It is characterised by markedly elevated serum IGG4 levels and tissue infiltration by IgG4 positive plasma cells. To date, 34 cases of IgG4 related hypophysitis have been described but only a handful were in women or biopsy proven. We describe a case of a 58 year old woman who presented with transient headache. She also complained of polyuria and nocturia. She had a thyroidectomy f...