Searchable abstracts of presentations at key conferences in endocrinology

ea0065cmw1.2 | Salt & Water | SFEBES2019

Diabetes insipidus – management challenges and pitfalls

Hannon Mark

Diabetes insipidus (DI) is a clinical syndrome characterised by inappropriate hypotonic polyuria. Urine flow rates in excess of 40 mL/kg per 24 h in adults, or more than 100 mL/kg per 24 h in infants are suggestive of diabetes insipidus. Correct diagnosis often requires the use of the water deprivation test. DI may be central or nephrogenic, and results in inappropriate renal water loss. The majority of patients with DI are able to maintain a normal plasma sodium even in the a...

ea0037s3.1 | Non-classical causes of hypopituitarism (<emphasis role="italic">Endorsed by Endocrine Connections</emphasis>) | ECE2015

TBI: whom to screen for hypopituitarism

Hannon Mark

Traumatic Brain Injury (TBI) is a devastating neurological emergency, usually resulting in transient or permanent neurological dysfunction. It is the most common cause of death and disability in young adults in industrialised countries and is a major public health problem. Although anatomical pituitary damage following TBI was first recognised as long ago as 1918, evidence of hormonal dysfunction in both the acute and chronic phases following TBI had only been studied in detai...

ea0021p229 | Growth and development | SFEBES2009

Familial growth hormone deficiency – response to growth hormone therapy and analysis of the GH-1 and GHRH-R genes

Hannon Mark , Crowley Vivian , O'Halloran Domhnall

Familial isolated growth hormone deficiency is exceedingly rare. We present two siblings of non-consanguineous parents with this syndrome and describe their response to growth hormone therapy. We have also carried out a mutational analysis of their GH1 and GHRH-R genes.A mutation scan of the entire coding region and flanking intronic sequences of GH-1 and GHRH-R was undertaken in both index cases and parents. GH1 and GHRH-R mu...

ea0034p3 | Bone | SFEBES2014

The utility of bone turnover markers in Paget's disease of bone

Hannon Mark J , Frizelle Isolda M , Kilbane Mark , McKenna Malachi J

Bone turnover markers (BTMs) may have a role in assessing bone turnover and response to intervention in Paget’s disease. We examined the clinical utility of bone turnover markers at diagnosis through analysis of our database of patients with radiographically confirmed Paget’s disease.We identified 36 patients (20 men); mean age at diagnosis was 71.6 years (range 54–84). Radionuclide imaging identified that 64% had polyostotic disease, with...

ea0014p507 | (1) | ECE2007

Gastric electrical stimulation in patients with severe diabetes mellitus associated gastroparesis – a cost benefit analysis

Hannon Mark J , Yousif Obada , Dineen Sean , Thompson Christopher J , O’Halloran Domhnaill J , Quigley Eamonn MM

Introduction: The management of diabetic gastroparesis resistant to medical therapy is very difficult – the most severely affected patients often spend many days as hospital inpatients with intractable nausea and vomiting and consequent dehydration, leading to a marked reduction in quality of life. Recently, gastric pacing (also known as gastric electrical stimulation (GES)) has been tried in these patients as a means of correcting the physiological deficit. It has shown ...

ea0013p72 | Clinical practice/governance and case reports | SFEBES2007

A cost benefit analysis of gastric electrical stimulation (GES) in patients with severe diabetic gastoparesis

Hannon Mark , Yousif Obada , Dineen Sean , Thompson Christopher J , Quigley Eamonn MM , O’Halloran Domhnaill J

Introduction: Patients who are severely affected with diabetic gastroparesis tend to spend many days as hospital inpatients with intractable nausea and vomiting and consequent dehydration. In patients who do not respond to promotility agents, gastric electrical stimulation (GES) is an option. This is a relatively new therapeutic modality which has shown promise in international trials. It has seen use in a very limited number of patients in Ireland. Here we outline our experie...

ea0037gp.04.02 | Steroids | ECE2015

The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure

Sherlock Mark , Behan Lucy Ann , Hannon Mark , Alonso Aurora Aragon , Thompson Christopher , Murray Robert , Crabtree Nicola , Hughes Beverly , Arlt Wiebke , Agha Amar , Toogood Andrew , Stewart Paul M

Context: Patients with hypopituitarism have increased morbidity and mortality. There is ongoing debate around the optimum glucocorticoid replacement therapy.Objective: To assess the effect of glucocorticoid replacement in hypopituitarism on corticosteroid metabolism and its impact on body composition.Design and patients: We assessed the urinary corticosteroid metabolite profile (using gas chromatography/mass spectrometry) and body ...

ea0037ep92 | Adrenal cortex | ECE2015

Long-term outcome from unilateral adrenalectomy in patients with primary aldosteronism

Hannon Mark J , Sze Candy , Carpenter Robert , Parvanta Laila , Matson Matthew , Sahdeve Anju , Druce Maralyn R , Waterhouse Mona , Akker Scott A , Drake William M

Primary aldosteronism (PA) is an important cause of hypertension which confers significant cardiometabolic risk. In approximately half of cases, the cause is a surgically resectable unilateral aldosterone-producing adrenal adenoma, making PA the most common potentially curable form of hypertension. Despite this, long-term data on surgical outcomes that could be used to guide discussions with patients are sparse. Here, we report on clinical outcomes several years post-adrenalec...

ea0037ep744 | Pituitary: clinical | ECE2015

Symptoms of gonadal dysfunction are more predictive of hypopituitarism than non-specific symptoms in screening for pituitary dysfunction following moderate or severe traumatic brain injury

Hernandez Martin Cuesta , Hannon Mark J , Crowley Rachel K , Behan Lucy Ann , Tormey William , Rawluk Daniel , Delargy Mark , Agha Amar , Thompson Christopher J

Context: The economic and logistic burden of screening for hypopituitarism following moderate/severe traumatic brain injury (TBI) is considerable. Published guidelines suggest prioritisation for screening of patients with symptoms of pituitary dysfunction.Objective: To evaluate the implementation of targeted symptom-based screening for hypopituitarism after moderate/severe TBI, compared with routine consecutive screening.Design: Gr...

ea0031p364 | Thyroid | SFEBES2013

Clinical performance of fine-needle aspiration biopsy of thyroid nodules in a tertiary referral centre

Glynn Nigel , Hannon Mark , Lewis Sarah , Hillary Patrick , Hill Arnold D K , Keeling Frank , Morrin Martina , McHenry Claire , Smith Diarmuid , Thompson Chris , Leader Mary , Agha Amar

Fine-needle aspiration biopsy (FNAB) is the tool of choice for evaluating thyroid nodules but there is a significant percentage of insufficient or indeterminate aspirates and falsely reassuring results have been reported in up to 6% of cases.We aimed to examine our experience with FNAB among a large cohort of unselected patients with thyroid nodules.239 consecutive patients (211 women) underwent FNA of a thyroid nodule between July...