Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep23 | Adrenal and Cardiovascular Endocrinology | ECE2023

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

Dreyer Anja Fenger , Borresen Stina Willemoes , Hansen Simon Boggild , Al-Jorani Hajir , Bislev Lise Sofie , Boesen Victor Brun , Christensen Louise Lehmann , Glintborg Dorte , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Lund Marie Louise , Stankovic Jelena , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Background: Glucocorticoid (GC) formulations are widely used as anti-inflammatory treatment, and synthetic GC, e.g. prednisolone, is the cornerstone treatment of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA). Long-term pharmacological GC treatment may induce adrenal insufficiency (GIA). Adrenal function is, however, not routinely assessed after discontinuation of long-term GC treatment, and it is unknown, if hydrocortisone replacement is beneficial. This study aim...