Searchable abstracts of presentations at key conferences in endocrinology

ea0062wc10 | Workshop C: Disorders of the thyroid gland | EU2019

A case of thyroid hormone resistance due to mutation in THRβ gene

Shah Usman , Hanson Philippa

A 25 year old gentleman was referred to the endocrine clinic for evaluation of abnormal thyroid function tests. He reported symptoms of diffuse abdominal pain associated with loose stool up to six times a day with urgency, frequency and tenesmus. These symptoms had been present since childhood, becoming increasingly troublesome over the preceding two years. He also reported symptoms of tiredness, palpitations and sweating episodes. Thyroid function tests were abnormal. TSH was...

ea0015p239 | Pituitary | SFEBES2008

BMP2 effects on Id1 expression and cell proliferation in LβT2 cells are receptor specific

Hanson Philippa , Milligan Tom , Burrin Jacky

The pathogenesis of gonadotrophin secreting pituitary tumours (gonadotrophinomas) remains poorly understood. BMP2, known to be important in the control of cell proliferation and differentiation, is essential for commitment of undifferentiated pituitary cells to the gonadotroph cell lineage. Attenuation of its expression is critical in allowing terminal differentiation. BMPs are associated with up-regulated expression of Id (Inhibitors of differentiation) proteins with predicte...

ea0028p77 | Clinical practice/governance and case reports | SFEBES2012

Haemofiltration as a treatment for severe, resistant hypercalcaemia

Pittaway James , Raja Omair , O'Toole Sam , Gunganah Kirun , Srirangalingam Umasuthan , Hanson Philippa , Drake William

Introduction: We describe two patients admitted to our institution with severe hypercalcaemia, resistant to conventional treatment, requiring haemofiltration. Patient 1 was admitted to hospital with profound hypercalcaemia (5.8 mmol/L) secondary to primary hyperparathyroidism (PTH >263 Pmol/L). The hypercalcaemia had been discovered on a surgical admission 3 months previously and was being managed with 0.9% normal saline and pamidronate infusions at an outside hospital. On...

ea0015p263 | Pituitary | SFEBES2008

Endoscopic transphenoidal pituitary surgery: results in 21 consecutive patients with Cushing’s disease

Hanson Philippa , Akker Scott , Monson John , Alusi Gus , Sabin Ian , Drake Will

Introduction: We present the outcome for the first 21 patients undergoing neuronavigation–guided, endoscopic transphenoidal surgery for pituitary dependent Cushing’s disease in our centre since August 2001. All operations were consecutive, and undertaken by the same neurosurgeon and endoscopic nasal surgeon.Methods: Records are available for 20 cases. Pre and post operative management of cases was led by the endocrine team with standard assessm...

ea0044ep30 | (1) | SFEBES2016

Hypercalcaemia induced psychosis due to primary hyperparathyroidism in pregnancy

Thomas Alice , Gunganah Kirun , Rayanagoudar Girish , Williams Eliot , Hanson Philippa , Drake Williams , Berney Daniel , Parvanta Laila , Kirwin Simon , Metcalfe Karl

Background: Primary hyperparathyroidism is the third most common endocrine condition in pregnancy after thyroid disease and diabetes. Untreated hypercalcaemia due to primary hyperparathyroidism increases the risk of miscarriage, intrauterine death and preterm labour. Pharmacological and surgical limitations in pregnancy often make diagnosing and managing this condition challenging. We report a complex case of hypercalcaemia-induced -psychosis due to primary hyperparathyroidism...