Searchable abstracts of presentations at key conferences in endocrinology

ea0031p299 | Pituitary | SFEBES2013

The effect of mTOR blockers on japanese quail ovarian granulosa cell functions

Kadasi Attila , Maruniakova Nora , Kolesarova Adriana , Balazi Andrej , Hanusova Emilia , Kotwica Jan , Mai Antonello , Sirotkin Alexander V

The aim of our study was to elucidated the role of mTOR-dependent intracellular signalling pathway in control of ovarian functions. For this purpose, we have examine the effect of three mTOR inhibitors (resveratrol, curcumin and synthetic mTOR blocker MC 2183 – Mai et al. 20051, at the doses 0, 1, 10, 100 μg/ml) on apoptosis and steroidogenesis by cultured Japanese quail ovarian granulosa cells. The release of steroid hormones (progesterone and te...