Searchable abstracts of presentations at key conferences in endocrinology

ea0002oc21 | Growth Regulation | SFE2001

Periconceptual undernutrition in the sheep causes premature activation of the hypothalamic-pituitary-adrenal (HPA) axis resulting in preterm birth

Bloomfield F , Oliver M , Hawkins P , Challis J , Harding J

Objective: to investigate whether periconceptual undernutrition in sheep alters the timing and activation of the fetal HPA axis and thus pregnancy duration. Preterm birth is a major health problem, but its causes are poorly understood.Methods: Twentyeight nulliparous ewes were randomly assigned to an ad libitum (N, n=8) or restricted diet (maternal body weight reduced by 15-20%; UN, N=10) from 61 d before to 30 d after mating. Therea...

ea0003p38 | Clinical Case Reports | BES2002

Sustained improvement in vision in a recurrent growth hormone secreting macroadenoma during treatment with octreotide in the absence of marked tumour shrinkage. A reason for cautious optimism ?

Harding J , Sheridan B , Atkinson A

A 45-year-old lady presented with a 12-month history of blurred vision. Visual assessment revealed a bitemporal hemianopia and CT scan demonstrated a large pituitary tumour with lateral and suprasellar extension. A GTT showed her growth hormone was raised basally at 7.5 milliunits per litre and incompletely suppressed to 5.7 milliunits per litre confirming acromegaly. Transsphenoidal hypophysectomy was performed. Histology confirmed a somatoptroph adenoma. Post operatively she...

ea0003p39 | Clinical Case Reports | BES2002

Hyperprolactinaemia in a patient taking the herbal remedy Agnus Castus

Harding J , Sheridan B , Atkinson A

A 34-year-old woman, presented to her General Practitioner with hot flushes. Investigations showed her to have a normal LH, FSH, free T4 and TSH. Her prolactin was elevated at 1110 milliunits per litre (NR <350 ). She had a normal menarche age 14 and had regular 28 day menstrual cycles. Before the onset of the hot flushes she had started to take agnus castus, a herbal remedy said to help symptoms of premenstrual tension.Whilst she continued to take ...

ea0003p28 | Clinical Case Reports | BES2002

Cushing's syndrome of indeterminate origin. Sucessful treatment of a liver abscess after therapy with a block and replacement medical regimen

Harding J , Kennedy A , Sheridan B , Atkinson A

A 67 yr old lady was admitted with left ventricular failure, angina, and atrial fibrillation. She was hypokalaemic (2.5mmol/l). There was a 3 year history of hypertension and a new diagnosis of diabetes mellitus. There was a recent history of weight gain, muscle weakness, bruising and facial puffiness. On examination she appeared cushingoid. A 24 hour urine for free cortisol was 1438nmol\/24h (normal<350). A basal 0800h serum cortisol was 1061nmol/l. After low dose dexameth...

ea0005p79 | Diabetes, Metabolism and Cardiovascular | BES2003

Identification of the gene causing familial juvenile hyperuricaemic (Gouty) nephropathy

Stacey J , Turner J , Harding B , Kotanko P , Lhotta K , Puig J , Roberts I , Torres R , Thakker R

Gout, which is commonly associated with hyperuricaemia, affects 0.2% of the population. Hyperuricaemia has a heterogeneous aetiology that may be due to either over production and/or reduced renal clearance, of urate. In order to identify the mechanisms underlying reduced excretion of urate, we undertook positional cloning studies of familial juvenile hyperuricaemic nephropathy (FJHN), which is an autosomal dominant disorder characterised by hyperuricaemia, a low fractional ren...