Searchable abstracts of presentations at key conferences in endocrinology

ea0019p373 | Thyroid | SFEBES2009

Further evidence for a key role of FcGR2a in autoimmunity

Yesmin K , Hargreaves C , Newby P , Brand O , Heward J , Franklyn J , Gough S , Simmonds M

Autoimmune diseases (AIDs) have been shown to share a series of genetic susceptibility loci, including the HLA class II region, CTLA-4 and PTPN22, indicating the sharing of key pathways between diseases. Recently, the rs1801274 single nucleotide polymorphism (SNP) within the Fc gamma receptor 2a gene (FcGR2a) has been shown to be associated with several common AIDs including type 1 diabetes, rheumatoid arthritis and coeliac disease. FcGR2a is an immune mod...