Endocrine Abstracts

The intraperitoneal environment of the ovarian surface epithelium (OSE) has an oxygen (O2) tension of 5–12%. This could impact cellular events leading to ovulation. Furthermore, ovarian cancers arising from the OSE (∼80–90% of ovarian malignancies) are likely to experience increased hypoxia due to the relatively poor vascularisation of solid tumours.Using 1%, 5% or 20% O2, we measured the expression of HSD11B1, COX-2...

At least 90% of human ovarian cancers originate in the OSE. Most studies indicate that EOC is oestrogen responsive. Paradoxically, ovarian cancer generally occurs after the menopause, which raises the question if oestrogen is involved, where does it come from? We hypothesise that the high circulating concentrations of conjugated (inactive) oestrogens in post-menopausal women are substrates for formation of active oestrogen in the OSE through the hydrolytic enzyme activity of S...

Abdominal surgery and diseases such as endometriosis cause persistent abdominal adhesions leading to pelvic pain, infertility and in severe cases, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (LOX) is a key enzyme required for crosslinking and deposition of insoluble collagen.10–12 weeks old female C57Bl/6 mice (3–10 mice per gro...

Introduction: A change in the biological behaviour of Small-Intestinal Neuroendocrine Tumours (SiNETs), as reflected by an increase in the Ki-67 proliferation index may occur over time. The purpose of this study was to evaluate longitudinal changes in Ki-67 indices of SiNETs and assess the impact of these in overall survival (OS).Patients and methods: We screened 551 patients with SI-NETs diagnosed from 1993, through 2021, identified using the SI-NET dat...