ea0094oc1.3 | Bone and Calcium | SFEBES2023
, Cassidy Ben
, Crastin Ana
, Poologasundarampillai Gowsihan
, Hardy Rowan
, Harper Lorraine
, Jones Simon W.
, Sagmeister Michael
Background: Osteoporosis is a common feature of chronic kidney disease (CKD), associated with premature mortality. Glucocorticoids (GCs) are steroid hormones, that in excess, can drive the suppression of bone formation. We have shown that the glucocorticoid (GC) activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is dysregulated in CKD, where it may contribute to the suppression of bone formation. We utilised a murine model of CKD with...