Searchable abstracts of presentations at key conferences in endocrinology

ea0028mte5 | (1) | SFEBES2012

The surgical approaches to MEN1 - what the endocrinologist needs to know

Harrison Barney

Controversy exists in the surgical treatment of patients with MEN 1 in relation to the timing and extent of interventions. Hyperparathyroidism in MEN 1 is caused by multiglandular disease and associated with high risk of supernumary glands. The findings on preoperative ultrasound and MIBI scans should not deter the surgeon from removing at least 3 parathyroid glands and the cervical thymus (1). Even subtotal parathyroidectomy (3½ glands) is associated with time dependant ...

ea0013s58 | Differentiated thyroid cancer | SFEBES2007

Surgical management of differentiated thyroid cancer (DTC)

Harrison Barney

The aims of effective surgical treatment of DTC are the provision of local control, the prevention of loco-regional relapse and when required the facilitation of adjuvant radioiodine therapy.Best practice involves a requirement to tailor the extent of thyroid and lymph node surgery to the risk of local and systemic relapse and the avoidance of over treatment and morbidity related to the laryngeal nerves and parathyroid glands. A preoperative diagnosis of...

ea0048wh2 | Workshop H: Miscellaneous endocrine and metabolic disorders | SFEEU2017

An unusual presentation of multiple endocrine neoplasia 1 (MEN1)

Pittaway James , Sahdev Anju , Harrison Barney , Newell-Price John , Drake William

Case history: A 36 year-old man was referred to our department for further evaluation of a large adrenal and multiple liver mass lesions. These had been found on an abdominal ultrasound requested for a 3 week history of mild, episodic abdominal pain. He was asymptomatic but described mild night sweats for over 10 years.Investigations, results and treatment: Hyperparathyroidism was evident, with a serum corrected calcium 3.04 mmol/l (2.15–2.65), PTH ...

ea0058oc4.3 | Oral Communications 4 | BSPED2018

Recommendations for management of paediatric phaeochromocytoma/paraganglioma (PCC/PGL): On behalf of the UK Paediatric PCC/PGL Guideline Development Group

Katugampola Harshini , Harrison Barney , Quek Samuel , Yadav Prateek , Spoudeas Helen , Marks Stephen

Background: Phaeochromocytoma/paraganglioma (PCC/PGL) are rare in children and young people (CYP) under 19 years of age. National registry data reveal an annual incidence between 0.2 and 0.3 per million in 5–9 and 10–14 year age groups respectively. Almost all result from a genetic predisposition and can present a significant management challenge.Aims: We aimed to provide the first interdisciplinary management guidelines using the AGREEII frame...

ea0034p81 | Clinical practice/governance and case reports | SFEBES2014

The patient with broken heart

Solomon Alexandra Lubina , Iqbal Ahmed , Harrison Barney , Webster Jonathan , Bennet William

A 58-year-old gentlemen presented with severe neckache, sweating, feeling hot, and cold. PMH included hypertension and MI. On examination, he was clammy, with blood pressure (BP) 205/107 mmHg. Laboratory results showed leucocytosis 28.5 and TroponinT 2002 ng/l (reference range <14.0). ECG showed inferolateral ST depression. CT angiogram showed a normal aorta and a 6 cm right adrenal mass. An echocardiogram showed severe LV impairment and normal valves.<p class="abstext...

ea0028p142 | Neoplasia, cancer and late effects | SFEBES2012

Monitoring patients with succinate dehydrogenase (SDH) mutations – A single centre experience

Venkataraman Hema , Taylor Sophia , Debono Miguel , Harrison Barney , Bull Mathew , Newell-Price John

Background: SDH mutations cause about 80% of familial pheochromocytomas / paragangliomas (1). Although mutations in each subunit are associated with a particular clinical spectrum of disease, there is no clear genotype-phenotype correlation of a specific mutation, nor with penetrance of disease. We report characteristics of patients with SDH mutations seen in a single dedicated tertiary referral clinic.Methods: A retrospective observational study of pati...

ea0066oc2.1 | Oral Communications 2 | BSPED2019

National United Kingdom evidence- and consensus-based guidelines for the investigation, treatment and long-term follow-up of paediatric craniopharyngioma

Gan Hoong-Wei , Morillon Paul , Albanese Assunta , Aquilina Kristian , Barkas Konstantinos , Chandler Chris , Chang Yen-Ch'ng , Daousi Christina , Drimtzias Evangelos , Farndon Sarah , Jacques Tom , Korbonits Marta , Kuczynski Adam , Limond Jennifer , Robinson Louise , Simmons Ian , Thomas Nick , Thomas Sophie , Thorpe Nicola , Vargha-Khadem Faraneh , Warren Daniel , Zebian Bassel , Gamble Ashley , Wilne Sophie , Harrison Barney , Spoudeas Helen , Mallucci Conor

Aims: Although rare, craniopharyngiomas are the commonest suprasellar tumour in childhood. Despite high overall survival, children and young people <19 years with craniopharyngiomas are at risk of multiple relapses and long-term tumour- and treatment-related morbidity. We sought to provide, for the first time, a national standard for best practice based on currently available evidence for the assessment, treatment and follow-up of paediatric craniopharyngiomas under the au...