Searchable abstracts of presentations at key conferences in endocrinology

ea0014p28 | (1) | ECE2007

Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic β-cells

Kudo Takanori , Ogawa Yoshiji , Suga Sechiko , Tomotsune Ken , Hasegawa Noriyuki , Suda Toshihiro , Wakui Makoto

A sustained, high circulating level of free fatty acids (FFAs) is an important risk factor for the development of insulin resistance, islet beta-cell dysfunction, and pathogenesis of type 2 diabetes. Here, we report a novel mechanism of chronic exposure of oleic acid (OA)-induced rat insulin release impairment. Following a 4-day exposure to 0.1 mM OA, there was no significant difference in basal insulin release when comparing OA-treated and untreated islets in the presence of ...