Searchable abstracts of presentations at key conferences in endocrinology

ea0075m08 | Metabolic Bone | EYES2021

Safety and efficacy of PTH 1-34 and 1-84 therapy in chronic hypoparathyroidism: a meta-analysis of prospective trials

Hasenmajer Valeria , Puliani Giulia , Sada Valentina , Tarantino Chiara , Lenzi Andrea , Isidori Andrea

Introduction: Hypoparathyroidism is the only endocrine deficiency for which replacement therapy with the missing hormone is not part of the clinical practice. High quality evidence on the use of PTH 1-34 or PTH 1-84 in hypoparathyroidism is missing.Objective: We aim to evaluate the efficacy and safety of PTH 1-34 and PTH 1-84, and to compare the two treatments when possible.Methods: We searched databases up to March 2021 for random...

ea0081p280 | Adrenal and Cardiovascular Endocrinology | ECE2022

Coagulation parameters in asymptomatic patients with adrenal incidentaloma: is mild autonomous cortisol secretion correlated with thromboembolic risk?

Minnetti Marianna , Bonaventura Ilaria , Hasenmajer Valeria , De Alcubierre Dario , Tomaselli Alessandra , Ferrari Davide , Pofi Riccardo , Cozzolino Alessia , Sbardella Emilia , Lenzi Andrea , Isidori Andrea

Background: Overt hypercortisolism is highly associated with venous thromboembolism. Patients with Cushing’s syndrome (CS) typically show an alteration of the intrinsic coagulation pathway, especially an increase in factor VIII (f-VIII), and increased levels of coagulation inhibitors (i.e., antithrombin III) as a compensatory response. Mild autonomous cortisol secretion (MACS) has been variably associated with higher risk of cardiovascular events and mortality compared to...

ea0090p278 | Adrenal and Cardiovascular Endocrinology | ECE2023

Bone metabolism and dual-release Hydrocortisone: results from a real-life study

Ferrari Davide , Sada Valentina , Hasenmajer Valeria , De Alcubierre Dario , Puliani Giulia , Minnetti Marianna , Cozzolino Alessia , Bonaventura Ilaria , Tomaselli Alessandra , Pofi Riccardo , Lenzi Andrea , M. Isidori Andrea

Background: Patients with adrenal insufficiency (AI) require long-term glucocorticoid (GC) replacement therapy and generally show an increased prevalence of bone metabolism alterations. Only few data are available on bone safety of dual-release Hydrocortisone (DR-HC) therapy.Objective: To evaluate bone metabolism in both primary AI (PAI) and secondary AI (SAI) during long-term therapy with DR-HC.Methods: We studied patients with AI...

ea0090p555 | Adrenal and Cardiovascular Endocrinology | ECE2023

Coagulation parameters in patients with adrenal incidentalomas and mild cortisol secretion: sex difference matters

Bonaventura Ilaria , Minnetti Marianna , De Alcubierre Dario , Tomaselli Alessandra , Ferrari Davide , Sada Valentina , Angelini Francesco , Hasenmajer Valeria , Cozzolino Alessia , Sbardella Emilia , Pofi Riccardo , Lenzi Andrea , Isidori Andrea M.

Background: Patients with Cushing’s syndrome (CS) typically show an alteration in the intrinsic coagulation pathway, leading to an increased risk of venous thromboembolism. Cortisol autonomy has been variably associated with higher risk of cardiovascular events and mortality compared to patients with non-functioning adrenal adenomas (NFA), particularly in women younger than 65 years. However, dedicated studies describing coagulation status in patients with adrenal inciden...

ea0063gp196 | Adrenal and Neuroendocrine - Clinical | ECE2019

Sexual function in adrenal insufficiency: data from the DREAM trial

Hasenmajer Valeria , Sbardella Emilia , Pozza Carlotta , Simeoli Chiara , Mazzotta Paola , Lecis Claudio , Lenzi Andrea , Pivonello Rosario , Angelo Jannini Emmanuele , Gianfrilli Daniele , Marcello Isidori Andrea

Introduction: Adrenal Insufficiency (AI) is characterized by absolute or relative deficiency of glucocorticoids and adrenal androgen precursors. Patients with AI show an impaired quality of life, metabolic status, immune function and dysregulated circadian genes. Data on sexual function are scarce and often contradictory. The aims of the present study are to evaluate sexual dysfunction (SD) in women and men patients with AI and to investigate the effects of restoring a more ph...

ea0063p463 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

InfeCtious disease in patients with Adrenal endocRinOpathies: the ICARO prospective observational study

Minnetti Marianna , Hasenmajer Valeria , Sbardella Emilia , Angelini Francesco , Bonaventura Ilaria , Simeoli Chiara , Chiloiro Sabrina , Pozza Carlotta , Gianfrilli Daniele , De Marinis Laura , Pivonello Rosario , Lenzi Andrea , Isidori Andrea M

Introduction: Cushing’s Syndrome (CS) is associated with an increased frequency and severity of infections. Mild hypercortisolism (MI) from adrenal incidentalomas has been associated with various complications, but data on infections are scarce. Retrospective data on patients with adrenal insufficiency (AI) showed an increased mortality attributed to infections. The approach used was very heterogeneous for all these studies. The aim of the study is to prospectively evalua...

ea0049gp16 | Adrenal 2 | ECE2017

Cardiovascular features of autonomous cortisol secretion in patients with adrenal incidentalomas

Sbardella Emilia , Minnetti Marianna , Rizza Laura , Giorgio Maria Rosaria Di , Hasenmajer Valeria , D'Aluisio Denise , Morelli Sergio , Lenzi Andrea , Isidori Andrea M

Background: Possible Autonomous Cortisol Secretion (pACS) is a condition found in 1–29% of patients with adrenal incidentalomas. The diagnosis of pACS has been variably associated with an increased risk of cardiovascular events and mortality. However, dedicated studies describing the morphologic and functional cardiac alterations in these patients are lacking.Aim: To compare the cardiovascular features of patients with pACS to those with nonfunction...

ea0056oc13.4 | The curious case of growth hormone | ECE2018

Effects of pegvisomant on glucose metabolism in acromegaly: A meta-analysis of prospective interventional studies

Feola Tiziana , Cozzolino Alessia , Puliani Giulia , Sbardella Emilia , Gianfrilli Daniele , Hasenmajer Valeria , Simonelli Ilaria , Pasqualetti Patrizio , Lenzi Andrea , Isidori Andrea M.

Introduction: Glucose metabolism impairment is a common complication of acromegaly. Pegvisomant (PEG) is used as second-line medical treatment in acromegaly. Data from literature suggest a positive effect of PEG on glucose metabolism but a meta-analysis has never been performed.Aim: To address the following questions: i) does PEG affect glucose metabolism? ii) does the effect correlate with disease control?Methods: We performed a m...

ea0075p11 | Pituitary and neuroendocrinology | EYES2021

Pituitary adenoma consistency is associated with postoperative hormonal deficits: a retrospective study on 50 patients undergoing transsphenoidal adenomectomy

De Alcubierre Dario , Pofi Riccardo , Sbardella Emilia , Puliani Giulia , Hasenmajer Valeria , Sada Valentina , Zaccagnino Antonella , Ruggeri Andrea G. , Gianfrilli Daniele , Isidori Andrea M.

Background: Little is known about possible predictors for hormonal function following pituitary surgery. Tumor consistency has recently emerged as a key factor in surgical planning for pituitary adenomas, influencing both the surgical outcome and the onset of postoperative complications. However, its impact on postoperative endocrine function has yet to be explored.Objectives: To evaluate the impact of tumor consistency on the development of postoperativ...

ea0093oc3 | Oral communication 1: Adrenal Diseases | EYES2023

Preoperative 1 mg dexamethasone suppression test predicts hypothalamus–pituitary–adrenal axis recovery: A one-year retrospective study of adrenal incidentalomas undergoing unilateral adrenalectomy

Bonaventura Ilaria , Tomaselli Alessandra , Angelini Francesco , Ferrari Davide , De Alcubierre Dario , Sada Valentina , Minnetti Marianna , Hasenmajer Valeria , Cozzolino Alessia , Sbardella Emilia , Isidori Andrea , Pofi Riccardo

Background: The evaluation of postoperative adrenal insufficiency (PAI) and hypothalamus–pituitary–adrenal (HPA) axis recovery in patients with adrenal incidentaloma (AI) undergoing unilateral adrenalectomy remains limited.Objectives: We aimed to identify predictive factors for PAI development and evaluate HPA axis recovery in AI patients undergoing unilateral adrenalectomy.Methods: We retrospectively analysed adrenal fun...