ea0038oc6.4 | Advances in reproduction and signalling | SFEBES2015
Gorvin Caroline
, Hastoy Benoit
, Breitwieser Gerda
, Rorsman Patrik
, Thakker Rajesh
The calcium-sensing receptor (CaSR), a class C G-protein coupled receptor (GPCR) is critical for calcium homeostasis. The presence of CaSR at the plasma membrane (PM) is regulated by a balance between internalisation via clathrin-mediated endocytosis, and agonist-induced PM insertion from intracellular receptor pools, in a mechanism known as agonist-driven insertional signalling. Recently, mutations of the clathrin-mediated endocytic adaptor protein-2 sigma subunit, AP2σ,...