Abstract Search

ea0086ec1.3 | Clinical Endocrinology Trust Best Abstract Clinical | SFEBES2022

Individuals on levothyroxine have higher HADS anxiety and depression scores than the general population and this is exacerbated by the Thr92Ala substitution in DIO2

Taylor Peter , Haug Eirin , Heald Adrian , Premawardhana Lakdasa , Okosieme Onyebuchi , Stedman Michael , Asvold Bjorn , Dayan Colin

Introduction: Around 15% of people diagnosed with primary hypothyroidism remain significantly symptomatic despite TSH normalisation with levothyroxine (LT4). The Thr92Ala substitution (rs225014) in a key deiodinase that activates T4 to T3, DIO2 may influence tissue levels of T3 but previous studies have been inconsistent regarding symptoms on LT4 and the presence of this polymorphism.Methods: We assessed HADS anxiety and depression scores in the HUNT2 st...

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ea0092op-08-02 | Oral Session 8: Hypothyrodism / Nodules | ETA2023

Individuals on levothyroxine have higher hads anxiety and depression scores than the general population and this is exacerbated by the THR92ALA substitution in DIO2, particularly at higher doses

Taylor Peter , Haug Eirin , Hanna Stephanie , Heald Adrian , Stedman Mike , Premawardhana Lakdasa , Okosieme Onyebuchi , Olav AEsvold Bjorn , Dayan Colin

Context: Approximately 15% of people with hypothyroidism remain symptomatic despite treatment. The Thr92Ala substitution in DIO2, may influence T3 tissue levels.Methods: We assessed HADS anxiety and depression scores in HUNT2 in 50,901 individuals (6,687 homozygous for Thr92Ala) of whom 1,480 had a history of levothyroxine use (180 homozygous for Thr92Ala). Anxiety and depression caseness (score>=8) by levothyroxine and Thr92Ala status was a...

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ea0101op-10-02 | Oral Session 10: Thyroid dysfunction-2 | ETA2024

Towards personalized TSH reference ranges: a genetic and population-based approach in three independent cohorts

Kuś Aleksander , Sterenborg Rosalie , Haug Eirin , Galesloot Tessel , Edward Visser W. , Smit Johannes W.A. , Bednarczuk Tomasz , Peeters Robin , Olav AEsvold Bjorn , Teumer Alexander , Medici Marco

Background: Serum thyroid-stimulating hormone (TSH) measurement is the diagnostic cornerstone for primary thyroid dysfunction. There is high inter-individual, but limited intra-individual variation in TSH concentrations, largely due to genetic factors. The currently used wide population-based reference intervals may lead to inappropriate management decisions.Methods: A polygenic score (PGS) including 59 genetic variants was used to calculate genetically-...

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Endocrine Abstracts

Individuals on levothyroxine have higher HADS anxiety and depression scores than the general population and this is exacerbated by the Thr92Ala substitution in DIO2

Individuals on levothyroxine have higher hads anxiety and depression scores than the general population and this is exacerbated by the THR92ALA substitution in DIO2, particularly at higher doses

Towards personalized TSH reference ranges: a genetic and population-based approach in three independent cohorts

BiosciAbstracts