Searchable abstracts of presentations at key conferences in endocrinology

ea0078p2 | Adrenal | BSPED2021

Glucose regulation and cardiovascular health in children and young people (CYP) with primary adrenal insufficiency: preliminary data (GRACE study)

Park Julie , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: The cardiovascular and metabolic outcomes of patients with AI are poor, and may be related to the non-physiological cortisol profile achieved with hydrocortisone treatment. Objectives: To describe salivary adrenal biomarkers, glucose and 24 hour ambulatory blood pressure (ABP) profiles, carotid intima media thickness (CIMT) and flow mediated dilatation (FMD) in CYP with primary AI, to improve knowledge of the relationship between non-physiolo...

ea0085oc5.7 | Oral Communications 5 | BSPED2022

Salivary cortisol and cortisone in healthy children and young people

Dliso Silothabo , Park Julie , Jones Lily , Bright Orla , Shantsila Alena , Hawcutt Daniel , Lip Gregory , Blair Joanne

Background: Cortisol is inactivated to cortisone in the salivary gland by 11β-HSD type 2. Concentrations of cortisone and cortisone in saliva correlate strongly with serum cortisol concentrations (1). Only free, biologically active hormone is measured in saliva, testing is non-invasive and can be performed at home/school, reducing cost and inconvenience to families and NHS resources. We previously reported pilot data from healthy children and young people (CYP) (1). Here we de...

ea0085p3 | Adrenal 1 | BSPED2022

Mean glucose concentrations are increased, and cardiovascular risk factors are common in children and young people with secondary adrenal insufficiency (GRACE2)

Park Julie , Jones Lily , Dliso Silothabo , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Hypoglycaemia, possibly due to non-physiological hormone replacement, and poor cardiovascular outcomes are described in patients with adrenal insufficiency (AI), particularly in the adult population. In this study, we describe glucose profiles and risk factors for premature cardiovascular disease (CVD) in children with secondary AI (SAI).Methods: Participants underwent continuous glucose monitoring (CGM), for seven days (blinded Dexcom G6 mon...

ea0085p25 | Gonadal, DSD and Reproduction | BSPED2022

Salivary cortisol is increased in paediatric patients with turner syndrome, and the circadian rhythm is blunted: preliminary data from a pilot study

Jones Lily , Blair Joanne , Park Julie , Dliso Silothabo , Hawcutt Daniel , YH Lip Gregory , Shantsila Alena

Background: Increased hair cortisol concentrations are reported in Turner Syndrome (TS) patients compared to healthy controls (HC).(1) Increased cortisol exposure could contribute to cardiovascular, metabolic and bone morbidity in TS. Hair cortisol concentrations give no information about the circadian profile of cortisol, which is important for cardiovascular health. Cortisol is inactivated to cortisone by 11β hydroxysteroid dehydrogenase (11βHSD) type-2 and regener...

ea0085p2 | Adrenal 1 | BSPED2022

Salivary adrenal biomarkers differ depending on age and sex in healthy children: preliminary data

Park Julie , Jones Lily , Dliso Silothabo , Bright Orla , Walker Laura , Grasim Ionela , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Saliva is ideal for measuring free, biologically active hormones. Measurements of salivary androgens may be valuable in diagnosis and monitoring of adrenal disorders, however the diurnal profile and robust reference ranges in healthy children are currently undefined. We report salivary testosterone, androstenedione (A4), 11-ketotestosterone (11-KT), 11-β hydroxyandrostenedione (11β-OHA4) concentrations measured throughout the day in healthy children.<...

ea0027p32 | (1) | BSPED2011

Steroid dose, age and gender affect adrenal responses to a low dose short Synacthen test in children with asthma

Hawcutt Daniel , Jorgensen Andrea , Gardner Christopher , Peak Matthew , Couriel Jonathan , Lacy David , Newland Paul , Didi Mohamed , Pirmohamed Munir , Smith Rosalind , Blair Joanne

Background: The activity of the hypothalamic–pituitary–adrenal axis (HPA) during inhaled corticosteroid (ICS) treatment of asthma has been studied extensively. To date patient populations have been too small or homogeneous to identify relationships between steroid exposure, patient characteristics and HPA activity. In this abstract we report data from a large, heterogeneous cohort of patients recruited to observational and pharmacogenomic studies.<p class="abstex...