Searchable abstracts of presentations at key conferences in endocrinology

ea0007p187 | Reproduction | BES2004

Effects of oral nomegestrol acetate, a 19 norprogesterone-derived progestin on the reproductive axis and lipids in men

Hay C , Wu F

Objectives: To assess the gonadotrophin suppressive effects of 2 doses of nomegestrol acetate (NOMA) alone and in combination with testosterone enanthate (TE) in men.To evaluate the potential effects of NOMA on circulating lipids in menMethods: Twelve healthy male volunteers were recruited. Subjects were randomly allocated to receive either NOMA 5 milligrams or NOMA 10 milligrams orally daily. Study duration included 28 days treatm...

ea0007p192 | Reproduction | BES2004

Intramuscular testosterone (T) undecanoate for the treatment of male hypogonadism: a parallel-group randomised open-label pharmacokinetic study

Hay C , Wu F

Objective: To identify the optimal regime for physiological replacement in hypogonadism. We assessed the pharmacokinetics of 3 different dose-intervals for i.m. administration of the new parenteral formulation of testosterone undecanoate in castor oil (Schering AG Berlin).Methods: Ten hypogonadal subjects (primary n equals 4 or secondary n equals 6) with a baseline T at diagnosis of less than 7 nanomols per litre were recruited and randomly allocated int...

ea0005p42 | Clinical Case Reports | BES2003

The use of intravenous etomidate infusion in the acute control of life-threatening hypercortisolaemia in a case of ACTH-dependent Cushing's syndrome

Hay C , Eddleston J , Wu F

A 59 year old woman was referred for further management of Cushings syndrome confirmed in another hospital. Presenting features included proximal myopathy, hypertension and hypokalaemia. Corticotrophin releasing hormone testing suggested an ectopic ACTH source.Within 48 hours of admission for petrosal sinus sampling, the patient acutely deteriorated with type 1 respiratory failure requiring ventilatory support. A chest radiograph and computed tomography scan revealed a rig...

ea0005p41 | Clinical Case Reports | BES2003

Incidental non secretory pituitary adenoma in a case of ectopic ACTH induced Cushing's syndrome

Hay C , Adams J , Teasdale G , Wu F

A 31 year old man with a 12 month history of uncontrolled hypertension was referred for further investigation. He complained of easy bruising, muscle weakness and severe back and hip pains. Clinical signs included cushingnoid facies, centripetal obesity, atrophic skin, peripheral oedema and BP of 150/104. Initial investigations confirmed Cushing's syndrome with 24 hour urinary free cortisol 696 nanomols per litre and 9am plasma cortisol 658 nanomols per litre following midnigh...

ea0007p80 | Endocrine tumours and neoplasia | BES2004

FSH-secreting pituitary gonadotroph adenoma producing ovarian hyperstimulation

Norris A , Hay C , Wilding M , McDowell G , Laing I , Holland J , McNeilly J , McNeilly A , Davis J

A 28-year-old Asian female presented with a 2 year history of abdominal pain and bloating and irregular heavy periods. She had a normal menarche and had 3 uncomplicated pregnancies after conceiving naturally, the last 4 years before presentation. Investigations showed LH 0.7 IU/l (normal range 2-14 IU/l), FSH 8.6 IU/l (2-14 IU/l), oestradiol 2030 pmol/l (80-300 pmol/l), prolactin 346 mU/l, and normal alpha GSU (0.3mcg/l). Ultrasound scanning revealed enlarged multicystic ovari...