Endocrine Abstracts

Introduction: In the UK alone, diabetes affects nearly 4 million people and an additional 13.6 million people are estimated to be at high risk of developing type 2 diabetes (T2DM). Diabetes is associated with vascular complications which path the development of cardiovascular diseases such as strokes and heart attacks. Previous studies have shown various pathways in which hyperglycaemia leads to endothelial dysfunction and insulin resistance. However, current reports of <e...

Introduction: Overweight and obesity is a worldwide chronic disease affecting 2 billion adults and millions of children. In diet-induced obesity (DIO), current treatments are not always effective or suitable for all patients due to the complexity of obesity and its associated health complications. Recently, the potential of developing weight loss therapy by targeting the gut microbiota has been raised. Previously, we have shown that mice overexpressing insulin-like growth fact...

Background: In obesity the relationship between white adipose tissue expansion and neovascularisation becomes uncoupled leading to inadequate perfusion of adipose tissue. Under these circumstances the secretory profile of adipocytes becomes metabolically unfavourable and pro-atherosclerotic. Therefore, targeting white adipose tissue may provide a potential therapeutic strategy to combat the negative metabolic and cardiovascular consequences of obesity. Here, we validated a mur...

Type 2 diabetes is preceded by insulin resistance, followed by increased endothelial cell production of superoxide and reduction in bioavailability of the vasoprotective signalling molecule, nitric oxide (NO). We demonstrated in preclinical models that type 2 diabetes also causes resistance to insulin-like growth factor-1 (IGF-1) mediated glucose lowering and endothelial NO release. This study aimed to examine the effect of the endothelial cell-specific combination of insulin ...