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ea0031p332 | Steroids | SFEBES2013

Truncal fat distribution is associated with enhanced glucocorticoid excretion, increased 5α-reductase activity and higher insulin resistance independent of BMI in women with polycystic ovary syndrome

O'Reilly Michael , Hodson James , Crabtree Nicola , Hazlehurst Jon , Stewart Paul , Tomlinson Jeremy , Arlt Wiebke

Polycystic ovary syndrome (PCOS) is a clinical triad of anovulation, hyperandrogenism and insulin resistance. Patterns of fat distribution in PCOS may be associated with androgen activation, glucocorticoid metabolism and insulin resistance. Here we analysed the relationship between fat distribution, steroid metabolism and insulin resistance in women with PCOS.We compared results from 100 PCOS patients (Rotterdam criteria) with 80 sex- and BMI-matched con...

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Endocrine Abstracts

Truncal fat distribution is associated with enhanced glucocorticoid excretion, increased 5α-reductase activity and higher insulin resistance independent of BMI in women with polycystic ovary syndrome

BiosciAbstracts