Searchable abstracts of presentations at key conferences in endocrinology

ea0082we3 | Workshop E: Disorders of the gonads | SFEEU2022

Polycythaemia related to exogenous testosterone administration

Page Tristan , Hazlehurst Jonathan

This 60-year-old male was reviewed remotely for follow up in the general endocrine outpatient clinic having originally been referred for erectile dysfunction and low libido. He had a past medical history of hypertension and dyslipidaemia and was prescribed amlodipine and atorvastatin. On previous clinical assessments, he had increased muscle bulk, normal secondary sexual characteristics with testes measuring 15mls and 12mls. There had been no evidence of gynaecomastia. He work...

ea0065p96 | Bone and calcium | SFEBES2019

Primary hyperparathyroidism in pregnancy – successful pregnancy outcomes in a series of five cases

Kalaria Tejaskumar , Hazlehurst Jonathan , Rahim Asad

Primary hyperparathyroidism is rarely diagnosed in pregnancy; not only because it is uncommon in that age group but also because many of the symptoms overlap with non-specific pregnancy symptoms (nausea, vomiting, fatigue, constipation). Primary hyperparathyroidism with significant hypercalcaemia can potentially cause serious maternal (preeclampsia, nephrolithiasis, pancreatitis and hypercalcaemic crisis) and foetal (miscarriage, stillbirth, neonatal hypocalcaemia leading to t...

ea0065p400 | Thyroid | SFEBES2019

An abnormal TSH can persist throughout pregnancy following gestational transient thyrotoxicosis and is not associated with increased maternal or foetal risk: a single centre retrospective cohort study

Black Annabel , Hazlehurst Jonathan , Rahim Asad

Introduction: Gestational transient thyrotoxicosis (GTT) affects 2–3% or pregnancies of European women and 11% of pregnancies of Asian women and typically resolves within the 2nd trimester. GTT rarely manifests with the typical symptoms of thyrotoxicosis and instead is associated with hyperemesis gravidarum. GTT can be confused with thyrotoxicosis occurring in pregnancy which requires prompt treatment with antithyroid drugs (ATDs) to minimise maternal and foetal risk. Inj...

ea0065p409 | Thyroid | SFEBES2019

Patients with hypothyroidism of differing aetiologies are often inadequately treated without appropriate dose adjustment: a retrospective cohort study based in primary and secondary care

Turton Sophie , Hazlehurst Jonathan , Rahim Asad

Introduction: Primary hypothyroidism is most commonly caused by autoimmune hypothyroidism whilst additional causes include post radioactive iodine treatment (RAI) whereas central hypothyroidism is typically associated with pituitary disease. Treatment in primary hypothyroidism aims to maintain the TSH within the reference range whilst treatment of central hypothyroidism is aimed at maintaining free T4 in the upper half of the reference range as established by intern...

ea0062p43 | Poster Presentations | EU2019

Thyroid storm - from clinic to intensive care

Chortis Vasileios , Hazlehurst Jonathan , Boelaert Kristien

Case history: A 46-year-old female patient presented to A&E with a three day history of diarrhoea and vomiting, after three months of progressive weight loss. Her past medical history included chronic autoimmune thrombocytopaenia and Graves’ disease, which had been diagnosed four years earlier and treated with a brief course of propylthyuracil (PTU). She was clinically in extremis, with signs of severe cardiovascular and respiratory compromise and reduced res...

ea0031p264 | Pituitary | SFEBES2013

A retrospective cohort study of patients with hyperprolactinaemia

Banner Alexandra , Hazlehurst Jonathan , Ayuk John

Hyperprolactinaemia is the most common endocrine disorder of the hypothalamic-pituitary axis and represents a significant referral volume to secondary care. It is therefore necessary to employ a timely, structured management pathway.This retrospective cohort study at University Hospitals Birmingham, included 450 patients with serum hyperprolactinaemia, measured between 2011 and 2012. Patients with a known hyperprolactinaemia were excluded. 71 patients re...

ea0094p193 | Bone and Calcium | SFEBES2023

Genetic Testing in Endocrinology: a clinical audit assessing the appropriate use, documentation, and communication of results

Madhotra Ruchika , Mundell Natasha , Hazlehurst Jonathan

Background: Confirming a genetic diagnosis earlier in patient pathways has multiple benefits: it informs and directs clinical management, enables patients to access support organisations, and helps patients adjust to their lifelong condition. This audit assessed the appropriate usage of genetic testing within Endocrinology at Birmingham Heartlands Hospital (BHH). The key three outcomes investigated were whether genetic testing was being appropriately ordered; ...

ea0065p309 | Neuroendocrinology | SFEBES2019

Post trans-sphenoidal pituitary surgery outcomes: single centre, single surgeon outcome data

Badawy Hannah , Hazlehurst Jonathan , Shad Mohammad , Rahim Asad

Introduction: Transsphenoidal pituitary surgery (TSPS) may be required either as a treatment for endocrinopathies or because of the risk or consequence of pituitary lesion expansion into adjacent structures, in particular optic chiasm compression. Published literature recommends surgery is performed by dedicated experienced surgeons with anticipated complication rates available as a comparator.Methods: This retrospective audit included all patients diagn...

ea0049ep728 | Steroid metabolism + action | ECE2017

Hepatic and adipose tissue insulin resistance as a consequence of intermittent hypoxia are exacerbated by glucocorticoid receptor antagonism in man

Hazlehurst Jonathan , Charlton Catriona , Mantripp Diana , Hodson Leanne , Tomlinson Jeremy

Introduction: Obstructive sleep apnea (OSA) affects up to 20% of a Western population and is associated with non-alcoholic fatty liver disease and type 2 diabetes (T2D). OSA is characterized by intermittent episodes of hypoxia (IH) that occur during sleep. It is not yet known if IH is directly linked to insulin resistance within key metabolic target tissues (adipose; liver and skeletal muscle) and what the potential underlying mechanism may be. It has been suggested that indiv...

ea0075o02 | Obesity, metabolism & miscellaneous endocrinology | EYES2021

A systematic review and meta-analysis of postoperative complications and outcomes in OAGB (one anastomosis gastric bypass) vs. RYGB (Roux-en-Y gastric bypass)

Chan Tin , Ong-Ying-Wei John , Hazlehurst Jonathan

Objectives: To report outcomes comparing RYGB (Roux-en-Y gastric bypass) and OAGB (one anastomosis gastric bypass) on patients with obesity. To further investigate the efficacy of OAGB, given that there is significant interest in OAGB as it has reported reduced operating time, better weight loss and increased remission of obesity-related comorbidities. However, there are concerns over potentially serious postoperative complications causing limited uptake.<p class="abstext"...