Searchable abstracts of presentations at key conferences in endocrinology

ea0028p364 | Thyroid | SFEBES2012

Acute deterioration in Grave’s opthalmopathy following total thyroidectomy

O'Shea Triona , Bacon Siobhan , Healy Ultan , Healy Marie-Louise

Acute deterioration in Graves Opthalmopathy (GO) has infrequently been described following total thyroidectomy. A 56 year old female smoker presented in January 2010. Thyroid function tests: TSH<0.01, free T4 (fT4) 47. Thyroid receptor antibody (TRAb) was raised at 31 (<1.5). She was commenced on carbimazole treatment. She had no GO at time of diagnosis. She discontinued carbimazole due to rash. She represented in December 2010 with symptoms of thyrotoxicosis. TSH<...

ea0065oc3.5 | Bone and Calcium | SFEBES2019

Mutational analysis of a patient with familial hypocalciuric hypercalcaemia identifies a novel p.Ser182Cys mutation, which is predicted to disrupt the calcium sensing receptor (CaSR) extracellular domain

Healy Ultan , Olesen Mie Kronborg , Jafar-Mohammadi Bahram , Hannan Fadil M , Thakker Rajesh V

Familial hypocalciuric hypercalcaemia (FHH) is an inherited disorder of calcium homeostasis, which is caused by germline loss-of-function mutations of the calcium-sensing receptor (CaSR) in ˜70% of cases. We report a 22 year old woman who was referred with asymptomatic hypercalcaemia. Biochemical investigations revealed hypercalcaemia on 3 of 4 occasions with adjusted serum calcium ranging from 2.59–2.80 mmol/l (normal range 2.20–2.60 mmol/l). Parathyroid hormon...

ea0065p155 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Carney’s triad due to SDHA gene mutation

Arabi Noon , Healy Ultan , Pal Aparna , Jafar-Mohammadi Bahram , May Christine

Carney’s triad; a diagnosis based on the presence of three associated neoplasms; epithelioid leiomyosarcoma, pulmonary chondroma, and extra-adrenal paraganglioma remains a rare diagnosis. Here we report a 52-year-old female investigated for chronic cough. Initial chest X-ray demonstrated calcified masses, and CT thorax confirmed a left pulmonary lesion measuring 41 mm in diameter with 3 adjacent smaller nodules up to 20 mm. A chondroid pattern o...

ea0060p21 | (1) | UKINETS2018

Utility of PRRT therapy in invasive intra-cardiac paraganglioma

Healy Ultan , Tadman Mike , Grossman Ashley , Weaver Andrew , Jafar-Mohammadi Bahram

We present the case of a 51-year-old woman who attends the NET service at the Oxford University Hospitals Trust with multiple known secretory paragangliomas (predominantly 3-methoxythyramine), including a carotid body tumour and, most recently, an intrapericardial paraganglioma. She is SDHC mutation positive. Multiple surgical resections of paragangliomas, at sites other than the cardiac lesion, had previously been undertaken. Due to disease progression and symptomati...

ea0074ncc9 | Highlighted Cases | SFENCC2021

A rare case of Hypocalcaemia – A diagnostic dilemma

Abeyaratne Dayakshi , Healy Ultan , Naziat Auditi , Tomlinson Jeremy , Pal Aparna , Hannan Fadil , Thakker Rajesh , Shine Brian , Jafar-Mohammadi Bahram

Case history: A 38-year-old woman presented with blepharospasm, cramping of the hands, and paraesthesia primarily affecting the face and hands. Symptoms had been present for 10 years but had been progressive over the previous 12 months. Symptoms were consistent with neuromuscular instability. Hypocalcaemia and elevated Parathyroid hormone (PTH) were confirmed. Past medical history was notable for anorexia nervosa in remission. Family history was non-contributary. Hypocalcaemia...

ea0068p31 | Abstracts | UKINETS2019

Transformation of non-functional metastatic pancreatic neuroendocrine tumour to functional insulinoma; a rare but recognised phenomenon

Anguelova Lia , Healy Ultan , Tadman Michael , Weaver Andrew , Fryer Eve , Patel Neel , Boardman Phillip , Soonawalla Zahir , May Christine , Pal Aparna , Grossman Ashley , Jafar-Mohammadi Bahram

We present the case of a 54-year-old woman with known metastatic non-functional pancreatic NET since 2004 that developed new debilitating recurrent hypoglycemia in 2013. The patient presented in 2004 with disseminated malignancy. Radiology revealed a large pancreatic mass associated with multiple liver lesions and abdominal lymphadenopathy. Liver biopsy confirmed well differentiated NET. Initial treatment with cisplatin etoposide chemotherapy was poorly tolerated and discontin...

ea0065p137 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Long term outcomes following parathyroidectomy in patients with multiple endocrine neoplasia type 1: A retrospective cohort study

Healy Ultan , English Katie , Bacon Hannah Elizabeth , Grossman Ashley B , Shine Brian , Thakker Rajesh V , May Christine JH , Pal Aparna , Mihai Radu , Jafar-Mohammadi Bahram

Primary hyperparathyroidism (PHP), usually due to multigland hyperplasia, occurs in >90% of patients with multiple endocrine neoplasia type 1 (MEN1). The literature is divided on the optimal surgical management for such patients. We report a retrospective cohort study on the long-term outcomes associated with limited, subtotal, or total parathyroidectomy as initial surgery for PHP in MEN1. The primary endpoint was recurrent PHP defined as an adjusted serum calcium >2.6 mmol/l ...

ea0065p285 | Neuroendocrinology | SFEBES2019

The argument for growth hormone day curve testing in acromegaly; significant discrepancy between mean growth hormone and random growth hormone levels

Healy Ultan , Kahn Shoaib , Vincent Alex , Martinez Jacinto , May Christine J H , Wass John , Shine Brian , Jafar-Mohammadi Bahram , Pal Aparna

Endocrine Society guidelines recommend random growth hormone (RGH) <1 mcg/l as indicative of biochemical control of acromegaly. Growth hormone (GH) control may also be determined using the mean GH (MGH) of a growth hormone day curve (GHDC). We report a retrospective analysis of 461 consecutive GHDCs, from 121 patients with treated acromegaly, performed in a single centre between 2009 and 2019. Each GHDC contained 7–9 GH measurements (mean 8.9) taken at regular interva...

ea0068p16 | Abstracts | UKINETS2019

Clinical characteristics and outcomes of 23 patients with insulinoma: a single centre retrospective observational study 2011–2018

Healy Ultan , Tadman Michael , Weaver Andrew , Fryer Eve , Bailey Adam , Patel Neel , Boardman Phil , Soonawalla Zahir , Pal Aparna , May Christine JH , Thakker Raj V , Grossman Ashley B , Jafar-Mohammadi Bahram

We report a retrospective, single centre observational study to determine the characteristics and outcomes of pancreatic insulinoma. Interrogation of the Oxford NET database, a departmental database of new NET MDT referrals since 2011 (n = 1059), revealed 23/1059 (2.1%) patients with insulinoma diagnosed and treated between 2011 and 2018. Patient records were reviewed and data was captured on demographics, presentation, investigations, treatments and outcomes: 15/23 (...

ea0065p280 | Neuroendocrinology | SFEBES2019

Prognostic indicators of metastatic neuroendocrine tumour of unknown primary site: a single centre retrospective study

English Katherine , Healy Ultan , Tadman Michael , Thakker Rajesh V , Talbot Denis , Abeyaratne Dayakshi , Silva Michael , Soonawalla Zahir , Fryer Eve , Shine Brian , Grossman Ashley B , Pal Aparna , May Christine , Weaver Andrew , Jafar-Mohammadi Bahram

Neuroendocrine tumours (NETs) presenting as metastatic cancer of unknown primary site (CUP) are suspected to confer poorer prognosis compared to metastatic NETs of known primary site. We performed a retrospective, single centre study to determine the prognostic indicators in CUP-NETs compared to metastatic small intestinal NET (SiNET), before and after adjusting for factors known to affect overall survival. Subjects were selected from a departmental database of 1050 NET patien...