Endocrine Abstracts

Aim: Beneficial effects of Jatropha tanjorensis (J. tanjorensis) extracts in African traditional medicinal practices for the management of type 2 diabetes have been reported. However, mechanisms through which these extracts exert their anti-diabetic actions have not been widely studied.Methods and materialsEffects of various aqueous extracts of root, leaf, and bark J. tanjorensis (0-1000 μg/ml) on insulin-release, cytotoxicity and cell viability were investigated using BR...

1=School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK 2= Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria3= IRiD Biosciences, Wilding Road, Ball Green, Stoke-on-Trent, ST6 8BQAim: Vernonia amygdalina extract is used traditionally for type 2 diabetes treatment in developing countries. Studies have reported antidiabetic properties of aqueous...

Aim: Gallic acid is one of the major bioactive phenolic compounds that have been isolated from several plant extracts with reported antidiabetic actions. However, insulinotropic effects and mechanisms underlying antidiabetic actions of garlic acid is poorly understood. This study investigated insulin-releasing and glucose-lowering effects of gallic acid.Methods: Glucose-stimulated insulin secretion in BRIN-BD11 cells were examined in the absence or prese...

Aim: The use of commonly consumed vegetables, such as Pterocarpus mildbraedii, in the treatment of metabolic conditions is consistent with the food-as-medicine strategy. To characterise its pharmacological actions, this study assessed insulin-releasing and glucose lowering effects of effects of P. mildbraedii in models of type 2 diabetes.Methods: Clonal pancreatic cells, BRIN-BD11, were treated P. mildbraedii extracts...