Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp198 | Adrenal and Neuroendocrine - Clinical | ECE2019

Analysis of circulating microRNAs in primary aldosteronism

Decmann Abel , Nyirő Gabor , Darvasi Otto , Turai Peter , Bancos Irina , Pezzani Raffaele , Kraljevic Ivana , Kastelan Darko , Parasiliti-Caprino Mirko , Nirschl Nina , Heinrich Daniel , Patocs Attila , Igaz Peter

Introduction: Primary aldosteronism (PA) is a major cause of secondary hypertension. The two major forms of sporadic PA (aldosterone producing adenoma – APA and bilateral adrenal hyperplasia – BAH) can only be reliably differentiated by adrenal venous sampling (AVS). Several mutations have been described for APA, but the pathogenesis of BAH is poorly elucidated. Differentiation of APA and BAH is clinically pivotal, as their treatment is different. There is no blood-b...

ea0063p34 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Aldosterone measurement in the Diagnosis of primary aldosteronism – comparison between two automated immunoassays and two liquid chromatography tandem mass-spectrometry methods

Fagotto Valentina , Uhl Olaf , Heinrich Daniel , Nirschl Nina , Sturm Lisa , Kratzsch Jurgen , Bae Yoon Ju , Fries Charlotte , Fenske Wiebke , Reincke Martin , Bidlingmaier Martin

Poor agreement between different analytical methods measuring aldosterone concentrations impedes applicability of uniform cut-offs in the diagnostic work-up of primary aldosteronism (PA). We compared 4 analytical methods (2 immunoassays and 2 LC-MS/MS) in plasma samples before and after saline infusion test (SIT). 80 hypertensive patients underwent the standardized diagnostic work-up within the German Conn’s registry. Patients (PA n=39/non-PA n=41) were ...

ea0070aep1001 | Hot topics (including COVID-19) | ECE2020

Obstructive sleep apnea in primary aldosteronism is associated with cortisol cosecretion

Heinrich Daniel , Adolf Christian , Handgriff Laura , Schneider Holger , Nirschl Nina , Obster Elisabeth , Sturm Lisa , Wang Xiao , Bidlingmaier Martin , Wildgruber Moritz , Ladurner Roland , Beuschlein Felix , Reincke Martin

Background: Primary aldosteronism (PA) is a secondary form of arterial hypertension that – in case of unilateral disease – can be cured by surgery. Multiple studies have shown that PA patients are at higher risk to suffer from cardiovascular events and to develop metabolic diseases. Two thirds of patients with PA suffer from obstructive sleep apnea (OSA). A bi-directional, pathophysiological interplay between OSA and PA has been proposed, with focus on overnight ro...

ea0081oc13.2 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Early post-operative ACTH-stimulated aldosterone predicts long-term biochemical outcome in primary aldosteronism

Bruedgam Denise , Adolf Christian , Schneider Holger , Wegmann Verena , Schwarzlmueller Paul , Mueller Lisa , Holler Finn , Lechner Benjamin , Handgriff Laura , Ladurner Roland , Deniz Sinan , Williams Tracy Ann , Beuschlein Felix , Reincke Martin , Heinrich Daniel

Introduction: Primary aldosteronism (PA) is the most common surgically curable cause for endocrine hypertension. Patients with unilateral aldosterone-producing adenoma undergo adrenalectomy (ADX). Clinical and biochemical outcome is assessed 6-12 months after ADX according to PASO consensus. To reduce unnecessary follow-up visits and change in medication for diagnostic purposes for potentially cured patients after ADX, a prediction tool is needed. Previous research had shown g...

ea0070aep1002 | Hot topics (including COVID-19) | ECE2020

Intact endothelial epoxyeicosatrienoic acids pathway in primary aldosteronism – the route to new treatment strategies?

Fruehbuss Laura , Meng Yao , Sun Jing , Gonzalez Marques Jair , Koletzko Berthold , Mederos Y Schnitzler Michael , Gudermann Thomas , Beuschlein Felix , Ann Williams Tracy , Heinrich Daniel , Adolf Christian , Reincke Martin , Schneider Holger

Rationale: Endothelial dysfunction (ED) is a hallmark of primary aldosteronism and paves the way for subsequent atherosclerotic disease. Past research has confirmed that one factor involved in ED is disturbed nitric oxide (NO) signalling. Since defects in NO release alone cannot explain the whole effect, we set out to address the role of endothelial CYP-expoygenase products (epoxyeicosatrienoic acids, EETs) in aldosterone-mediated endothelial dysfunction.<p class="abstext"...