Searchable abstracts of presentations at key conferences in endocrinology

ea0022s9.3 | The role of oxidative stress in the development of the metabolic syndrome | ECE2010

Marked improvement of insulin resistance by reduced age intake; a non-pharmacologic, non-nutrient based intervention for type 2 diabetes

Vlassara Helen

The clinical efficacy of strict glucose control against risk of diabetic macrovascular complications, despite effective treatment, has been disappointing, pointing to non-glucose related etiologic factors. Elevated inflammatory advanced glycation end products (AGEs), or Glycotoxins, known to increase the incidence and severity of diabetic complications, are recently shown to impair insulin production and insulin actions, hence are involved in the etiology of diabetes and insul...

ea0016p800 | Thyroid | ECE2008

Insulin resistance and oxidative stress induce advanced glycation end products formation in patients with clinical and subclinical hypothyroidism

Peppa Melpomeni , Hadjidakis Dimitrios , Alevizaki Maria , Dimitriadis George , Isari Georgia , Economopoulos Theofanis , Uribarri Jaime , Vlassara Helen , Raptis Sotirios A

Introduction: Advanced glycation end products (AGEs) formation is accelerated in various pathological conditions characterized by insulin resistance (IR) and/or increased oxidative stress (OS). Hypothyroidism – overt (OH) or subclinical (SUH) – is associated with a variety of metabolic disorders leading to IR and increased OS.Aim: To estimate the εN-carboxymethyl-lysine (CML) levels, in subjects with OH and SUH and seek f...