Searchable abstracts of presentations at key conferences in endocrinology

ea0066p2 | Adrenal, Gonadal, DSD and Reproduction, and Basic Science | BSPED2019

Variations in 17α-hydroxyprogesterone response to hydrocortisone treatment for congenital adrenal hyperplasia in children

Hendriks A Emile J , Oddy Sue , Halsall David J , Thankamony Ajay

Introduction: Hydrocortisone is the main treatment for congenital adrenal hyperplasia (CAH) in children. The optimal biochemical monitoring and replacement regimen of these children continues to be debated. We explored variations in blood spot 17α-hydroxyprogesterone (17-OHP) levels.Methods: Single centre retrospective cross-sectional study of children with 21-hydroxylase deficiency aged <18 years. Patients treated with hydrocortisone who had dr...

ea0058p049 | Diabetes | BSPED2018

Use of diluted insulin in the management of very young children with type 1 diabetes: case report and literature review

Hendriks A Emile J , Ewen Ross L , Hoh Yoke Sin , Bhatti Nazia , Williams Rachel M , Thankamony Ajay

Introduction: The management of type 1 diabetes (T1D) in young children can be extremely challenging due to high insulin sensitivity, unpredictable eating and activity and difficulty recognizing symptoms of hypoglycaemia. Continuous subcutaneous insulin infusion (CSII) therapy is beneficial in managing young children, however the small insulin doses required challenge the accuracy of standard concentration (100 IU/ml) CSII.Case report and literature revi...

ea0051oc2.1 | Oral Communications 2 | BSPED2017

Discordant TSH measurements in an euthyroid child due to a homozygous TSHbeta subunit gene variant with variable immunoreactivity

van Walree Eva , Hendriks A Emile J , Moran Carla , Nicholas Adeline K , Lyons Greta , McGowan Anne , Halsall David , Oddy Sue , Chatterjee V Krishna , Schoenmakers Nadia

Introduction: Thyroid function tests are frequently undertaken in children with non-specific symptoms suggestive of thyroid dysfunction. Infrequently, susceptibility of automated thyroid hormone assays to interference may generate misleading results, with the potential for inappropriate diagnosis and management. We report an unusual case with apparent subclinical hyperthyroidism, due to negative interference in particular TSH assay platforms, with an underlying genetic basis.<...