Searchable abstracts of presentations at key conferences in endocrinology

ea0014p276 | (1) | ECE2007

Transthyretin is up-regulated by androgens in mice liver and choroid plexus

Santos Cecilia RA , Henrique Alves C , Saraiva Maria Joao , Abreu Raquel , Baltazar Graça , Socorro Silvia , Quintela Telma P , Gonçalves Isabel MT

Transthyretin (TTR) is well documented as a carrier for thyroid hormones. It also binds retinol binding protein preventing its filtration trough the kidneys and therefore is involved in delivering retinol to target cells. Moreover, TTR sequesters amyloid-beta impairing its deposition in nervous tissues and possibly contributing to its removal. Despite its importance in mammalian physiology, there are few studies regarding the regulation of TTR synthesis. In silico analy...