Searchable abstracts of presentations at key conferences in endocrinology

ea0014p21 | (1) | ECE2007

Improved glucose metabolism and altered pancreatic structure in transgenic mice overexpressing betacellulin

Dahlhoff Maik , Herbach Nadja , Wanke Rüdiger , Wolf Eckhard , Schneider Marlon R.

Betacellulin, one of several peptides activating the EGFR (ErbB1) and related receptors, is a multipotent growth factor known to posses the unique ability to promote growth and differentiation of pancreatic β-cells.We investigated the effects of betacellulin overexpression in a recently established transgenic mouse model (Schneider et al., Endocrinology 146, 5237–5246, 2005). In transgenic animals, overall glucose metabolism was improved...

ea0035p83 | Bone and Osteoporosis | ECE2014

Low-carbohydrate/high-fat diets do not have negative effects on bone density in female rats in contrast to male rats

Zengin Ayse , Kropp Benedikt , Chevalier Yan , Horngacher Amon , Sustarsic Riia , Sustarsic Elahu , Benedix Sarina , Herbach Nadja , Milz Stefan , Bielohuby Maximilian , Bidlingmaier Martin

Ketogenic low-carbohydrate/high fat diets (LC-HFD) induce weight loss in both animals and humans. However, a number of unwanted side effects with these diets have been reported. We have previously shown in male rats that LC-HFDs negatively affect bone growth and bone mineral density, possibly due to macronutrient-induced impairments of the GH/IGF-system. Given the importance of dietary macronutrients in the regulation of bone density in male rats, in this study we investigated...