Endocrine Abstracts

Objective: This open-label, single-arm study assessed the long-term safety and efficacy of injectable testosterone undecanoate (TU; Nebido) in men with hypogonadism.Methods: Men aged 18–75 years with hypogonadism (baseline serum total testosterone <10 nmol/l) were recruited. The study was performed under conditions designed to resemble routine clinical management: patients with underlying conditions such as diabetes mellitus and hypertension wer...

Hypothalamic obesity caused by childhood–onset craniopharyngioma results in long–term cardiovascular morbidity. Knowledge about clinical markers and risk factors for cardiovascular morbidity is scarce. A cross–sectional study on transthoracic echocardiographic parameters was performed to determine the associations with clinical and anthropometric parameters in 36 craniopharyngioma patients. BMI correlated with the thickness of interventricular septum in diastole...

BackgroundObesity, cardiovascular disease (CVD), and relapse/progression have impact on prognosis in pediatric brain tumor (BT) patients.MethodsIn a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI follow-up monitoring as a parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy control...

PurposeChildhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). We investigated clinical manifestations and outcome in incCPs and symCPs.MethodsIncCP were discovered in 4 (3m/1f) and symCP in 214 (101m/113f) CP recruited 2007–2014 in KRANIOPHARYNGEOM 2007. Age, sex, height, body mass index (BMI), tumor volume, degree of resection, pre- and postsurgic...

BackgroundCerebral infarction (CI) is a known vascular complication following treatment of suprasellar tumors. Risk factors for CI, incidence rate, and long-term prognosis are unknown for patients with childhood-onset craniopharyngioma (CP).MethodsMRI of 244 CP patients, recruited between 2007 and 2019 in KRANIOPHARYNGEOM 2007, were reviewed for CI. Risk factors for CI and outcome after CI were analyzed.<...