Searchable abstracts of presentations at key conferences in endocrinology

ea0032s27.2 | Steroids in obesity and metabolism | ECE2013

Metabolic control through glucocorticoid hormones

Herzig Stephan

In the past decades, glucocorticoid (GC) hormones and their cognate, intracellular receptor, the glucocorticoid receptor (GR), have been well established as critical checkpoints in mammalian energy homeostasis. Whereas many aspects in healthy nutrient metabolism require physiological levels and/or action of GC, aberrant GC/GR signalling has been linked to severe metabolic disorders, including obesity, insulin resistance and type 2 diabetes. Consequently, molecular mechanisms w...

ea0016p498 | Obesity | ECE2008

Tribbles pseudokinases and adipose tissue biology

Ostertag Anke , Herzig Stephan

Obesity, insulin resistance and high cholesterol levels are hallmarks of the metabolic syndrome. The molecular players involved in the onset of the metabolic syndrome are mostly unknown. In this context the three pseudokinases of the tribbles family have emerged as potential candidates. Among them, TRB3 has been described as a negative regulator of Akt, a key player in insulin signal transduction. However, the biological functions of TRB family members remain largely unknown. ...

ea0016oc3.6 | Diabetes and obesity | ECE2008

Transcriptional control of hepatic and systemic lipid metabolism by the nuclear receptor co-factor RIP140

Diaz Mauricio Berriel , Krones-Herzig Anja , Vegiopoulos Alexandros , Herzig Stephan

Given the importance of transcriptional regulation in metabolic control, we investigated the role of nuclear receptor co-factors in the liver, a key organ in energy homeostasis. Here we show in mice that the expression of receptor interacting protein 140 (RIP140) in the liver is induced in catabolic states like fasting and cancer cachexia. In contrast, chronic high fat diet feeding reduced RIP140 mRNA levels in the liver. Increased hepatic RIP140 in catabolic conditions was as...

ea0016oc6.8 | Metabolism and cardiovascular | ECE2008

Chronic prostaglandin excess results in adipose tissue wasting through increased substrate utilization

Vegiopoulos Alexandros , Chichelnitskiy Evgeny , Ostertag Anke , Diaz Mauricio Berriel , Muller-Decker Karin , Herzig Stephan

Disruption of the balance in energy homeostasis and substrate metabolism can lead to obesity and the metabolic syndrome on one hand and body wasting in cachexia associated with cancer and other chronic diseases on the other hand. Indirect evidence suggests that prostaglandins (PGs), products of the cyclooxygenase (COX) pathway, are involved in the regulation of metabolic processes under physiological conditions or during disease, in particular cancer cachexia. However, the dir...

ea0081oc7.6 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

A tumor-borne Angpt2/Tie2 autostimulatory loop controls tumorigenesis

Pellegata Natalia , Minaskan Ninelia , Gulde Sebastian , Mohr Hermine , Geppert Julia , Rohm Maria , Vitale Giovanni , Gaudenzi Germano , Dicitore Alessandra , Franz Schilling , Schillmaier Mathias , Eisenhofer Graeme , Herzig Stephan , Roncaroli Federico , Honegger Jurgen

Background: Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non-resectable neoplasms associated to frequent relapse and significant comorbidities. As current treatments often fail against NF-PitNETs, identifying actionable therapeutic targets is essential. We focused on the angiopoietin-2 (Angpt2)/Tie2 axis, usually active in endothelial cells (ECs).Methods: ANGPT2 plasma levels in NF-PitNET patients and healthy controls were m...

ea0073oc7.5 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatic O-GlcNAcylated-p53 as a hub integrating the glucose counterregulatory response and insulin-suppressed gluconeogenesis

González Rellán María Jesús , Fernández Fondevila Marcos , Fernández Paz Uxia , Rodríguez Amaia , Varela Rey Marta , Veyrat-Durebex Christelle , Seoane Samuel , Bernardo Ganeko , Fernando Lopitz Otsoa , Fernandez Ramos David F , Bilbao Jon , Iglesias Cristina , Müller David F , Herzig Stephan , Martinez Chantar Maria Luz , Perez Fernandez Roman , Lopez Miguel , Diéguez Roman , Maria Mato Jose , Millet Oscar , Coppari Roberto , Woodhoo Ashwin , Fruhbeck Gema , Nogueiras Pozo Rubén

Background and aimsGlucose homeostasis is essential for life. The liver is among the key tissues for maintaining an adequate metabolic homeostasis and its alterations are at the root of the pathogenesis of many disease states. A perfect balance between glucose production, mainly at the liver, and glucose consumption in different tissues, is provided by the action of insulin and counterregulatory hormones as glucagon, cortisol or catecholamines. There is ...