Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep179 | Endocrine tumours and neoplasia | ECE2017

Serum succinate: investigation of its putative role as a new biomarker in malignant SDH-x mutated pheochromocytoma-paraganglioma patients?

Lamy Constance , Hadoux Julien , Mercier Lionel , Bailleux Dorian , Hescot Segolene , Paci Angelo , Baudin Eric , Broutin Sophie

Introduction: Malignant paraganglioma/pheochromocytoma (MPP) are very rare neuroendocrine tumors with heterogeneous prognostic and no gold-standard treatment. MPP can be associated with germline mutations at SDH-x genes which encode for the succinate dehydrogenase that catalyzes the oxidation of succinate to fumarate. SDH-x mutations lead to inactivation of the enzyme and thus accumulation of succinate.Aim: This project aims to evaluate...

ea0063p1027 | Interdisciplinary Endocrinology 2 | ECE2019

Immune-related endocrine toxicities in non-small cell lung cancer: predictors of outcome to checkpoint inhibitors?

Poli Roberta , Dumont Clement , Pietrogiovanna Lisa , Servois Vincent , Beaucaire-Danel Sophie , Daniel Catherine , Girard Nicolas , Romano Emanuela , Hescot Segolene

Background: Immune checkpoint inhibitors (ICIs) are approved for the treatment of non-small cell lung cancer (NSCLC) and are associated with specific immune-related adverse events (iRAEs) including endocrine toxicities. However, data concerning the type, occurrence, and dynamics of iRAEs and their predictive value on treatment outcome are lacking. In this study, we evaluated the relation of iRAEs to anti-PD/L1 (programmed cell death protein/ligand-1) ICIs focusing particularly...

ea0063oc7.2 | Endocrine Connections 1 | ECE2019

Thyroid hormones are new key regulators of glucocorticoid metabolism

Bessiene Laura , Hescot Segolene , Bourdin-Pintueles Alexandra , Dumeige Laurence , Vitellius Geraldine , Perrot Julie , Xu Qiong-Yao , Vu Thi-An , Sachs Laurent , Pussard Eric , Lombes Marc , Viengchareun Say , Martinerie Laetitia

The 11-beta hydroxysteroid dehydrogenase (11βHSD) isozymes are well-known regulators of glucocorticoid hormone metabolism: 11βHSD2, mostly expressed in the distal nephron, converts cortisol [F] into cortisone [E] in humans or corticosterone into 11-dehydrocorticosterone in rodents (11-dehydro derivatives being inactive compounds), and 11βHSD1, ubiquitously expressed but predominantly in the liver, catalyzes the opposite reaction. Under pathophysiological conditi...

ea0084op-03-14 | Oral Session 3: Advanced Thyroid Cancer | ETA2022

Entrectinib in patients with ntrk fusion-positive (ntrk-fp) thyroid cancer: Updated data from startrk-2

W Bowles Daniel , Bazhenova Lyudmila , Hescot Segolene , Folprecht Gunnar , Daga Haruko , Massarelli Erminia , P Conley Anthony , Lamartina Livia , Lin Jessica , Ahn Eugene , Osborne Stuart , Heinzmann Sebastian , Carrizosa Daniel

Objectives: NTRK gene fusions are oncogenic drivers in many solid tumours, including thyroid cancers. In the phase 2 study STARTRK-2 (NCT02568267), entrectinib (a CNS-active tropomyosin receptor kinase [TRK] inhibitor) demonstrated efficacy in patients with NTRK-fp thyroid cancer (objective response rate [ORR]: 40%; clinical cut-off: 31 Oct 2018; n=5). We report updated data from a larger cohort with longer follow-up.Methods: A...

ea0063p433 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Molecular events in a large series of advanced stage III-IV adrenocortical cancer: looking for new therapeutic options

De Martino Maria Cristina , Lacroix Ludovic , Aubert Sebastien , Libe Rossella , Al Ghuzlan Abir , de la Fouchardiere Christelle , Hescot Segolene , Assie Guillaume , Honore Aurelie , Deschamps Fred , Lombes Marc , Borson-Chazot Francoise , Pattou Francois , Pivonello Rosario , Borget Isabelle , Schlumberger Martin , Leboulleux Sophie , Scoazec Jean-Yves , Bertherat Jerome , Cao Christine Do , Baudin Eric

Adrenocortical cancer (ACC) is a rare cancer with poor prognosis and scant treatment options.Purpose: To look for new therapeutic approaches issued from the screening for common genetic variants in a large series of advanced ACC.Experimental design: Whole exome sequencing have been performed in 10 advanced (stage III and IV) ACC samples to identify the recurrent variants. The presence and the frequency of most interesting variants ...