Searchable abstracts of presentations at key conferences in endocrinology

ea0019p146 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Metformin decreases angiogenesis via ERK1/2/ERK5 pathways by increasing the anti-angiogenic adipokine thrombospondin-1

Tan Bee , Kumar S Prashanth , Chen Jing , Heutling Dennis , Mitchell Dan , Lehnert Hendrik , Randeva Harpal

Aims: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiovascular complications. Thrombospondin-1 (TSP-1) is a novel anti-angiogenic adipokine highly expressed in obese, insulin-resistant subjects. We sought to assess TSP-1 levels in adipose (AT) from PCOS women and matched controls. The effects of metformin treatment on circulating TSP-1 levels in PCOS subjects; effects of serum from normal and PCOS women on in vitro migration and...

ea0016oc6.4 | Metabolism and cardiovascular | ECE2008

Lipolysis in subcutaneous tissue after intranasal administration of ACTH(4-10) is associated with an increased baroreceptor reflex sensitivity

Wellhoner Peter , Horster Ruth , Jacobs Friederike , Sayk Friedhelm , Heutling Dennis , Lehnert Hendrik , Dodt Christoph

The melanocortin system plays a significant role in the hypothalamic regulation of body weight and energy expenditure. Prolonged central administration of the melanocortin receptor 4 (MC-4) agonist ACTH(4-10) reduces body weight in animals and humans by increasing energy expenditure and by reducing food intake. The aim of this study was to investigate the effect of intranasally administered alpha-MSH on local lipolysis in subcutaneous adipose tissue and on sympathetic nerve ac...

ea0019oc23 | Cardiovascular metabolism | SFEBES2009

Insulin increases and metformin decreases the novel adipokine chemerin in insulin resistant subjects: PCOS as a paradigm

Tan Bee , Chen Jing , Adya Raghu , Kaur Jaspreet , Heutling Dennis , Lewandowski Krzysztof C , Lehnert Hendrik , Randeva Harpal

Adipose tissue produces several hormones and cytokines termed ¬Ďadipokines¬í that have widespread effects on carbohydrate and lipid metabolism. They appear to play an important role in the pathogenesis of insulin resistance, diabetes, and atherosclerosis. Chemerin is a novel adipokine, highly expressed in obese, insulin-resistant subjects. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. We assessed chemerin levels in sera and adipose...