Searchable abstracts of presentations at key conferences in endocrinology

ea0027oc4.3 | Oral Communications 4 | BSPED2011

Non-linear dynamic analysis of glucose regulation in subjects with type 2 diabetes and controls: observed variability and lability (OVAL)

Hill Nathan , Hindmarsh Peter , Tsapas Apostolos , Matthews David

Introduction: Glucose homeostasis is central to the understanding of diabetes and is influenced by hormones and by substrate flux. This implies a non-linear system which has been confirmed by time series analysis. A dynamic systems approach is required for describing the inter-relationship of glucose and insulin and we describe a method that measures a mathematical domain of glucose homeostasis termed the observed variability and lability (OVAL).Methods:...

ea0027oc1.5 | Oral Communications 1 | BSPED2011

Deconvolution analysis of 24 h serum cortisol profiles informs the amount and distribution of hydrocortsione replacement therapy

Hindmarsh Peter , Hill Nathan , Dattani Mehul , Peters Catherine , Charmandari Evangelia , Matthews David

Introduction: Glucocorticoid replacement therapy uses twice or thrice daily regimens of hydrocortisone (HC) with variable distribution of the dose over the day. Deconvolution analysis determines the mass of hormone that needs to be secreted to attain a particular serum concentration. We have used this methodology to determine the amount and distribution of cortisol over a 24 h period.Methods: Seventy-nine adults (41M) aged 60–74 years and 30 childre...