Searchable abstracts of presentations at key conferences in endocrinology

ea0003oc29 | Metabolism | BES2002

Deleterious effect of non-esterified free fatty acids (NEFAs) on resistance artery endothelial function

Sainsbury C , Hillier C , Sattar N , Petrie J , Connell J

Elevated circulating concentrations of non-esterified free fatty acids (NEFAs) are observed in states of insulin resistance and may be associated with increased cardiovascular risk. We hypothesised that NEFAs directly impair endothelial NO bioavailability via increased oxidative stress, in addition to their proposed indirect effect via VLDL. The study was designed to investigate the effect of monounsaturated and saturated fatty acids on endothelium-dependent and -independent v...