Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep22 | Adrenal cortex (to include Cushing's) | ECE2016

Method-specific serum cortisol responses to the ACTH test: comparison of two generations of Roche automated immunoassays using polyclonal vs MABs

Klose Marianne , Hilsted Linda , Feldt-Rasmussen Ulla

Introduction: The plasma cortisol response to the ACTH test is known to vary significantly by assays. An automated cortisol immunoassays with increased specificity due to the shift from polyclonal to MABs, and standardized against mass spectrometry was recently introduced, with an expected decrease in cortisol concentrations by 20%. Cut-offs used in clinical practice for patient evaluation will thus have to be adjusted. We aimed to assess the normal cortisol response to ACTH s...

ea0090p439 | Pituitary and Neuroendocrinology | ECE2023

Serial sampling of dried blood spots collected by a novel automated body-worn system, Fluispotter®

Krogh Jesper , Plomgaard Peter , Frikke-Schmidt Ruth , Velschow Sten , Johannesen Jesper , hilsted linda , Schroeder Malene , Feldt-Rasmussen Ulla

Repeated blood sampling is required in certain clinical and research settings, which is currently performed by drawing blood from venous catheters requiring manual handling of each sample at time of collection. A novel body-worn device for repeated serial samples, Fluispotter®, with automated extraction, collection and storage of up to 20 venous dried blood spot samples (DBS) over the course of 20 h may overcome problems with current methods for serial sampling. The purpo...

ea0020p519 | Paediatric Endocrinology | ECE2009

Sex hormone-binding globulin levels predict insulin sensitivity, disposition index and cardiovascular risk during puberty

Soerensen Kaspar , Aksglaede Lise , Munch-Andersen Thor , Aachmann-Andersen Niels , Helge Joern , Hilsted Linda , Petersen Joergen , Juul Anders

Objective: Early puberty is associated with increased risk of subsequent cardiovascular disease. Low sex hormone-binding globulin (SHBG) levels are a feature of early puberty as well as conditions associated with increased cardiovascular risk. The aim of the present study was to evaluate SHBG as predictor of glucose metabolism and metabolic risk during puberty.Research design and methods: Cross-sectional study on 132 healthy Caucasian children and adoles...

ea0056p19 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal insufficiency during prednisolone treatment in patients with polymyalgia rheumatica or giant cell arteritis – prevalence and clinical approach

Willemoes Borresen Stina , Laursen Toke , Jensen Bente , Hilsted Linda , Marie Bartels Else , Feldt-Rasmussen Ulla , Locht Henning

Introduction: Prednisolone is standard treatment of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), but many patients are reluctant to discontinue prednisolone treatment even after remission of the inflammatory conditions. Prednisolone-induced adrenal insufficiency can give manifest or latent symptoms, causing failure to taper and withdraw prednisolone. We therefore aimed to find the prevalence of adrenal insufficiency in prednisolone-treated patients with PMR/GCA...

ea0037ep46 | Adrenal cortex | ECE2015

Adrenal insufficiency during prednisolone treatment: need for cortisol replacement strategies in patients on long-term low-dose glucocorticoid treatment?

Borresen Stina Willemoes , Baslund Bo , Klose Marianne , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hilsted Linda , Locht Henning , Hansen Annette , Hetland Merete Lund , Feldt-Rasmussen Ulla

Background: Patients on long-term glucocorticoid treatment are at risk of adrenal insufficiency during glucocorticoid treatment. The side effect can occur during glucocorticoid treatment if there is a mismatch between glucocorticoid requirements and production/intake. High-dose glucocorticoid treatment is often sufficient to overcome most stressful situations. A low-dose of 5 mg prednisolone/day is however, equivalent to 20 mg hydrocortisone, a dose often used as basal glucoco...

ea0035p35 | Adrenal cortex | ECE2014

Glucocorticoid-induced adrenal insufficiency in prednisolone treated patients and how it relates to glucocorticoid dose and the duration of treatment

Dinsen Stina , Baslund Bo , Klose Marianne , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hilsted Linda , Locht Henning , Hansen Annette , Feldt-Rasmussen Ulla

Objective: We aimed to assess the prevalence of glucocorticoid-induced adrenal insufficiency in prednisolone treated patients, and its relation to glucocorticoid dose and duration of treatment.Subjects and measures: As part of a larger study 48 patients with rheumatoid arthritis (33 women, aged 34–85 years) treated with a mean prednisolone dose of 7.0 mg (range 5–20 mg) per day, and a mean duration of treatment of 95 months (range: 6–360 m...

ea0049ep40 | Adrenal cortex (to include Cushing's) | ECE2017

Predictive baseline morning P-cortisol levels for the response to a Synacthen test in prednisolone treated patients

Borresen Stina Willemoes , Klose Marianne , Locht Henning , Laursen Toke , Jensen Bente , Hilsted Linda , Baslund Bo , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hansen Annette , Hetland Merete Lund , Feldt-Rasmussen Ulla

Introduction: Evaluation of glucocorticoid production generally requires a dynamic test. Cut-off levels for baseline cortisol concentrations predicting the outcome of a Synacthen test have been proposed for different cortisol assays. With introduction of the new Roche Elecsys Cortisol II assay, P-cortisol concentrations are expected to decrease by 20%. We have investigated cut-off levels for baseline P-cortisol concentrations measured with the Roche Elecsys Cortisol II assay t...