Searchable abstracts of presentations at key conferences in endocrinology

ea0028p314 | Steroids | SFEBES2012

Development of a highly sensitive and specific ultra high performance liquid chromatography tandem mass spectrometry method for the quantitation of aldosterone in human plasma

Hinchliffe Edward , Carter Stephanie , Owen Laura , Adaway Joanne , Keevil Brian

Introduction: Aldosterone is a potent adrenal steroid hormone which regulates renal sodium reabsorption and potassium secretion. Clinically, measurement of aldosterone is important to identify patients with primary hyperaldosteronism, and has traditionally been performed by immunoassay. The specificity of immunoassays is often poor due to antibody cross reactivity to other structurally related steroid hormones, resulting in falsely elevated concentrations. To overcome these li...