Searchable abstracts of presentations at key conferences in endocrinology

ea0013p277 | Steroids | SFEBES2007

The effect of septic serum on adenylyl cyclase and adrenocortical responsiveness in vitro and in vivo

Chung Teng-Teng , King Peter J , Hinds Charles , Clark Adrian J

Attenuation of the adrenocortical response to ACTH in septic shock is a well recognised phenomenon, although the underlying mechanisms remain poorly understood. The evidence points towards factors in septic serum that dampen the adrenocortical responsiveness. The aim of this work is to investigate the cellular function of adrenocortical cells in septic shock and to determine the components within serum that could influence their function. Septic rat serum was collected from ma...