Searchable abstracts of presentations at key conferences in endocrinology

ea0028p46 | Clinical practice/governance and case reports | SFEBES2012

Improvement of health-related quality of life in adult women with 21-hydroxylase deficiency over a 7 years period

Quinkler Marcus , Ventz Manfred , Hinz Andreas , Bleicken Benjamin

Introduction: Health related quality of life (HRQoL) is impaired in adult patients with 21-hydroxylase deficiency (21-OHD). Up to now, only cross-sectional and no longitudinal studies are available, and it is not known if HRQoL can be improved in adult 21-OHD patients. Objective: To investigate HRQoL in adult female 21-OHD patients over a longer time span.Methods: Longitudinal, single centre, follow-up study over seven years with three visits including 1...

ea0028p322 | Steroids | SFEBES2012

Modified-release prednisolone increases quality of life compared to standard prednisolone in patients with adrenal insufficiency

Quinkler Marcus , Ventz Manfred , Hinz Andreas , Langenheim Jorinde

Context: Patients with adrenal insufficiency (AI) receive glucocorticoid replacement therapy, which tries to imitate physiological adrenal secretion. However, the first glucocorticoid dose is usually given after waking in the morning resulting in a 3–5 h delay compared to physiological secretion. Impaired quality of life (QoL) might be, in part, due to this delayed dose scheme. Therefore, modified-release glucocorticoid preparations might have therapeutical advantages.</p...