Searchable abstracts of presentations at key conferences in endocrinology

ea0005p142 | Endocrine Tumours and Neoplasia | BES2003

Cell cycle dysregulation in parathyroid adenoma and carcinoma

Valentine G , Jordan S , Lu X , Lowe D , Hirace R , Korbonits M , Grossman A

While primary hyperparathyroidism is most commonly due to a parathyroid adenoma, very occasionally it may be secondary to a parathyroid carcinoma. A substantial minority of parathyroid adenomas are due to mutations or transpositions in genes in involved in the regulation of the cell cycle. In particular, at the cell cycle checkpoint which regulates exit from G1 phase, there is an interaction between the cyclins and cyclin-dependent kinases (CDKs); specifically, cyclin D intera...