Searchable abstracts of presentations at key conferences in endocrinology

ea0086ec1.4 | Clinical Endocrinology Trust Best Abstract Basic | SFEBES2022

Characterising the G-protein signalling mechanisms activated by short chain fatty acids in human enteroendocrine cells which mediate production and release of the anorectic gut hormones peptide YY (PYY) and glucagon-like peptide-1 (GLP-1)

Hirdaramani Aanya , Frost Gary , Hanyaloglu Aylin

The anorectic gut hormones glucagon-like peptide-1 (GLP-1) and Peptide YY (PYY) are secreted by enteroendocrine L cells in response to short chain fatty acids (SCFAs) produced by gut microbiota following dietary fibre consumption. SCFAs, acetate, propionate and butyrate, activate the G protein-coupled receptors Free Fatty Acid Receptor 2 and 3 (FFAR2, FFAR3). Increasing intestinal levels of propionate can prevent weight gain in overweight adults. In rodents, FFAR2-mediated gut...