Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp8 | Adrenal and Neuroendocrine - Tumour | ECE2019

Pheochromocytoma: Positive predictive values of mildly-elevated urinary fractionated metanephrines in a large cohort of community-dwelling patients

Hirsch Dania , Grossman Alon , Nadler Varda , Alboim Sandra , Tsvetov Gloria

Introduction: The importance of highly sensitive screening tests for pheochromocytoma/paragnaglioma (PPGL) is clear. However, a low level of specificity may lead to unnecessary biochemical and imaging investigations and even to needless surgical procedures. Therefore, in patients with elevated values of metanephrines, it is essential to establish a rational threshold for performing prompt thorough diagnostic investigations rather than opting for active surveillance.<p clas...

ea0073ep12 | Adrenal and Cardiovascular Endocrinology | ECE2021

Clinical, imaging and laboratory features of patients with adrenal incidentaloma referred to a tertiary medical center in recent years and a comparison with a historical institutional cohort

Yaacov Hadar , Tsvetov Gloria , Levy Sigal , Hirsch Dania

BackgroundThe term adrenal incidentaloma (AI) refers to the existence of an asymptomatic adrenal mass that was detected at random in an imaging test performed not in order to evaluate the adrenal glands. In recent years, the use of imaging tests has increased, and the resolution of the imaging studies has been improved. This trend may affect the characteristics of AIs at the time of diagnosis.ObjectiveInvesti...

ea0049ep1391 | Thyroid (non-cancer) | ECE2017

The impact of age and gender on the presentation and prognosis of medullary thyroid cancer – an Israeli multicenter study

Twito Orit , Grozinsky-Glasberg Simona , Benbassat Carlos , Llevy Sigal , Bachar Gideon , Gross David J , Hirsch Dania

Background: Data regarding the effect of gender and age on medullary thyroid cancer (MTC) presentation and prognosis is limited. Although older age and male sex were found to correlate with poorer prognosis in some studies, this correlation may reflect differences in MTC presentation between sex and age groups, or a mixture of hereditary and sporadic MTC forms.Objective: To evaluate the impact of age and sex on the presentation and outcomes of MTC.<p...

ea0081rc7.3 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Pituitary microadenoma vs macroadenomas in cushing’s disease: does size matter?

Akirov Amit , Shimon Ilan , Yosi Manisterski , Aviran-Barak Nirit , Nadler Varda , Alboim Sandra , Kopel Vered , Tsvetov Gloria , Hirsch Dania

Background: The majority of adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are less than 10 mm in diameter and are described as microadenomas, while corticotroph macroadenomas (≥10 mm) are a less common cause of Cushing’s disease. Prior reports on the differences of clinical and biochemical behavior of corticotroph microadenomas and macroadenomas were inconsistent.Objective: Describe the clinical and biochemical characteristic...

ea0081p255 | Late-Breaking | ECE2022

Cushing syndrome in older women: age-related differences in disease origin and clinical manifestations

Akirov Amit , Shimon Ilan , Yosi Manisterski , Aviran-Barak Nirit , Nadler Varda , Alboim Sandra , Tsvetov Gloria , Hirsch Dania

Background: Adrenocorticotropic hormone (ACTH)-producing pituitary adenoma is the most common cause of endogenous Cushing syndrome (CS), but the relative proportion of adrenal causes of CS is rising. Limited data are available on the clinical manifestations and cause of CS in older women.Objective: Determine the clinical presentation, biochemical profile, and cause of CS in women 65 years of age and older, compared with younger patients with CS.<p cl...

ea0049ep1374 | Thyroid (non-cancer) | ECE2017

Trends in the clinicopathological features and clinical outcomes of medullary thyroid carcinoma – an Israeli multicenter study

Hirsch Dania , Twito Orit , Levy Sigal , Bachar Gideon , Robenshtok Eyal , Gross David J , Mazeh Haggi , Benbassat Carlos

Background: The massive use of neck sonography has led to a dramatic increase in the incidence of thyroid cancer detection, predominantly small papillary carcinomas. However, changes in the presentation and course of medullary thyroid carcinoma (MTC) over time remain unclear.Objective: To evaluate trends in the presentation and outcomes of MTC.Methods: Patients treated for MTC at four medical centers in Israel were divided into two...

ea0037gp.20.03 | Pituitary – Hypopituitarism | ECE2015

Timing is everything? Postpartum pituitary dysfunction – variability of clinical and radiological presentation

Tirosh Amit , Iraqi Hiba Masri , Hirsch Dania , Robenshtok Eyal , Yoel Uri , Toledano Yoel , Twito Orit , Tsvetov Gloria , Shimon Ilan

Introduction: Two aetiologies are responsible for postpartum hypopituitarism; Sheehan’s syndrome which develops following traumatic labour, and lymphocytic hypophysitis. Since management of lymphocytic hypophysitis does not require surgery in most cases, pathology is usually absent, and the clinical presentation, in combination with laboratory and imaging characteristics establish the diagnosis. We aimed to describe the various patterns of presentation, including assistin...

ea0070aep946 | Thyroid | ECE2020

Papillary thyroid cancer with biochemical incomplete response: Clinico-pathological characteristics and disease outcome

Steinschneider Miriam , Asly Mustafa , Markus Efrat , Koren Shlomit , Tkacheva Inna , Benbassat Carlos , Muallem-Kalmovich Limor , Hirsch Dania

Objective: Althoughmost Papillary Thyroid Cancer (PTC) patients with biochemical incomplete response (BIR) to primary therapy have a good clinical outcome, some will develop disease progression. We aim to study baseline characteristics and long-term outcomes of PTC patients with BIR.Methods: Of 1049 PTC patients treated at 2 tertiary medical centers, 795 (75.8%) had excellent, 91 (8.7%) biochemical incomplete, 139 (13.2%) structural incomplete and 24 (2....

ea0056p209 | Calcium &amp; Vitamin D metabolism | ECE2018

Primary hyperparathyroidism in the elderly

Duskin-Bitan Hadar , Nemirovsky Nina , Slutzky-Shraga Ilana , Robenshtok Eyal , Diker-Cohen Talia , Shimon Ilan , Hirsch Dania , Tsvetov Gloria

Introduction: Primary hyperparathyroidism (PHPT) is the third most common endocrinopathy. Data on PHPT in the elderly are scarce.Objective: To characterize elderly patients with PHTP, clinically and biochemically.Patients: A total of 216 patients (73.6% females) aged≥75 years were diagnosed and followed at a single tertiary medical center for PHPT.Results: Mean follow-up was 11.3±5.5 years. Age at ...

ea0081oc6.4 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Clinical correlates of a large Israeli cohort of Cys 618 Arg RET mutation

Chava Rosenblum Rachel , Hirsch Dania , Glasberg Simona , Benbassat Carlos , Yoel Uri , Ishay Avraham , Lamprecht Sagit Zolotov , Bachar Gideon , Banne Ehud , Twito Orit

Introduction: A syndrome of MEN2A and Hirschsprung’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...