Searchable abstracts of presentations at key conferences in endocrinology

ea0049s30.1 | Moving away from old-fashioned steroidogenesis: what are the clinical implications? | ECE2017

Clinical relevance of alternative synthesis of androgens

Hofland Hans

Recent years have seen many exciting developments in the field of steroidogenesis. These include improved diagnostics through mass spectrometry, novel clinical relevance attributed to steroids previously deemed irrelevant and successful implementation of new anti-cancer treatments. Prostate cancer is a prime example of the latter with the recent confirmation that castration-resistant disease is still androgen-dependent and susceptible to hormonal manipulation with next generat...

ea0037ep37 | Adrenal cortex | ECE2015

Pregnancy-induced Cushing's syndrome

Andreescu Corina , Hofland Leo , Hofland Hans , Looijenga Leendert , de Herder Wouter , Feelders Richard

CushingÂ’s syndrome (CS) during pregnancy is a rare metabolic condition with only a few cases reported in the literature. Misdiagnosis of CS is common because of the overlapping features of fatigue, weight gain, striae, and emotional changes that occur during normal pregnancy. The clinical presentation together with laboratory and imaging findings help to make a diagnosis. However, changes in maternal hormones and their binding proteins complicate assessment of the normal ...

ea0070aep626 | Pituitary and Neuroendocrinology | ECE2020

Surgical and survival outcomes of early peptide receptor radionuclide therapy for downstaging locally advanced or oligometastatic pancreatic neuroendocrine neoplasms

Minczeles Noémie , van Eijck CHJ , van Gils MJ , van Velthuysen MF , Nieveen van Dijkum EJM , Feelders Richard , de Herder Wouter W , Brabander* T , Hofland* Hans

Introduction: Pancreatic neuroendocrine neoplasm (pNEN) patients often present with locally advanced or metastatic disease. The objective response rate of peptide receptor radionuclide therapy (PRRT) in pNENs is 55%. Therefore, PRRT may be a possibility for patients who are not eligible for upfront curative surgery.Aims: To assess the potency of PRRT to render locally advanced or oligometastatic pNENs resectable and to evaluate the effect of surgery afte...

ea0070aep801 | Reproductive and Developmental Endocrinology | ECE2020

11-Ketotestosterone is the Predominant Androgen in Castration Resistant Prostate Cancer

Snaterse Gido , van Dessel Lisanne F , van Riet Job , Taylor Angela E , Visser Jenny A , Arlt Wiebke , Lolkema Martijn P , Hofland Hans

Background: The treatment of metastatic castration-resistant prostate cancer (CRPC) remains dependent on Androgen Receptor (AR) mediated signalling, thus understanding all components involved in testosterone signalling in these men is of utmost importance. Recent studies have identified 11-ketotestosterone (11 KT) as a potent androgen receptor (AR) agonist present in humans. However, it is unknown if 11 KT is present at physiologically relevant concentrations in CRPC patients....

ea0073aep839 | Late Breaking | ECE2021

Neuroendocrine neoplasm of the pancreas as a manifestation of familial isolated pituitary adenoma: A case report

Coopmans Eva , Korpershoek Esther , M.F. van Velthuysen , Adrian F. Daly , Beckers Albert , Aart Jan Van der Lely , Neggers Sebastian , Hofland Hans , Feelders Richard , Wouter W de Herder

ContextGermline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) have been identified in patients with pituitary adenomas, most frequently presenting as somatotropinomas in the setting of familial isolated pituitary adenoma (FIPA). Our current understanding of AIP related tumorigenesis indicates that it leads to isolated pituitary adenomans, while other associated tumors have not typically been considered part of the...