Searchable abstracts of presentations at key conferences in endocrinology

ea0011p584 | Neuroendocrinology and behaviour | ECE2006

The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis

Agha A , Tomlinson J , Clark PM , Holder G , Stewart PM

The high dose short Synacthen (corticotropin) test (SST) is widely used to investigate suspected secondary adrenal insufficiency but concern remains about falsely reassuring results with potentially serious clinical consequences.In order to evaluate the long-term safety of the SST, we retrospectively evaluated the clinical outcome in 178 patients who achieved 30-minute cortisol values in the lowest 15th percentile of normal healthy responses. This subgro...

ea0005oc23 | Obesity and Diabetes | BES2003

Expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 are increased following weight loss

Tomlinson J , Shakespeare L , Holder G , Clark P , Stewart P

The global epidemic of obesity has heightened the need to understand the mechanisms that underpin its pathogenesis. Clinical observations in patients with Cushing's syndrome have highlighted the link between cortisol and central obesity. However, whilst circulating cortisol levels are normal or reduced in obesity, local regeneration of cortisol, from inactive cortisone, by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has been postulated as a pathogenic mechanism. W...

ea0003p263 | Steroids | BES2002

Growth hormone increases fat mass in patients with simple obesity

Tomlinson J , Crabtree N , Clark P , Holder G , Shackleton C , Stewart P

Patients with obesity are relatively Growth Hormone (GH) deficient. GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting pre-adipocyte proliferation. Conversely, we have shown that cortisol inhibits pre-adipocyte proliferation and enhances differentiation. Furthermore, GH, acting through IGF-1, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts the inactive glucocorticoid, cortisone (E) to active cortisol (F) in ad...